02293nas a2200241 4500008004100000245012400041210006900165260001800234300001200252490000600264520155900270653001901829653001501848653002001863653001501883653001001898100001801908700002501926700002101951700002101972700002301993856003502016 2017 eng d00aEvaluation of Anti Arthritic Potential of Gloriosa superba (L.) Elite Germplasm Collected from Eastern Himalayas, India0 aEvaluation of Anti Arthritic Potential of Gloriosa superba L Eli cNovember 2017 as87-s920 v93 a

Introduction: Gloriosa superba (L.) is a traditionally known medicinal plant for its potential antigout property. The species is rich source of colchicine alkaloid and is commercially exploit in the international market for the same. Method: In the present study, elite chemotype of G. superba was identified from natural population in Eastern Himalayas based on their colchicine content through HPTLC calibrated method. The selected elite chemotypes were further evaluated for in vitro anti-arthritic potential via inhibition of protein denaturation along with hydroxyl radical scavenging potential. Result: The HPTLC quantification data reveals that the content of colchicine varies from 0.044 to 0.184% having maximum content in NBG-128 from Jorhat, Assam. The results of bioassay reflect a potentiating anti-arthritic and hydroxyl radical scavenging with statistically insignificant difference within the elite germplasms. Conclusion: The presence of bioactive polyphenolics with significant hydroxyl radical scavenging will further suggest that inhibition of inflammatory mediator cells by extract is superimposed action of colchicine and other chemical inhibitors like polyphenolics. The study will aid in site specific exploration of high metabolite yielding chemotype(s) with validated pharmacological action for commercial cultivation to meet out the industrial demand of colchicine and herbal product development.

10aAnti arthritic10aColchicine10aElite chemotype10aG. superba10aHPTLC1 aMisra, Ankita1 aSrivastava, Akanksha1 aKhalid, Mohammad1 aKushwaha, Poonam1 aSrivastava, Sharad uhttp://fulltxt.org/article/387