08200nas a2200277 4500008004100000245015500041210006900196260001900265300001200284490000600296520729100302653001207593653000807605653002907613653002107642653001707663100003007680700003807710700002407748700002807772700002507800700002907825700002807854700000507882856003507887 2017 eng d00aPre and Post-Treatment Effects: Estimation of Serum Testosterone and Lipid Peroxidation Levels on Moringa olifera Extract Induced Cadmium Exposed Rats0 aPre and PostTreatment Effects Estimation of Serum Testosterone a cSeptember 2017 a846-8490 v93 a

Background: Cadmium (Cd), is a toxic metal which affects various organs including testis. It produces oxidative stress leading to male infertility. Moringa tree, is a natural plant with a great therapeutic value and hence it is found to be effective both in prevention and treatment of various conditions including reducing toxicity of hazardous materials. The aim of the present study was to examine the effects of Pre-and Post-treatment with Moringa oliefera leaf extract (MoE) on testis in cadmium exposed rats. Materials and Methods: The present study was conducted at the Department of Physiology, Kasturba Medical College (KMC), Mangalore, Manipal University (MU), Karnataka, India, between (2011-2013). This prospective study consisted a total of 30 rats. These were divided into 5 groups with group I being the control. Data were presented as mean ±SD. student’s t test was used as statistical tool, p<0.05 considered statistically significant. Group IV and V were pre-and post-MoE treated groups respectively. Serum testosterone and tissue lipid peroxidation levels were estimated. Results: Treatment with MoE prior and after administration of cadmium, respectively showed an increase significantly in the testosterone levels and a decrease in the tissue lipid peroxidation as compared to the group treated with cadmium. However, the pre-treatment showed better results in combatting the toxic effects of cadmium. Conclusion: This study shows that Moringa olifera leaf extract altered the testosterone and tissue lipid peroxidation levels. Also, pre-treatment showed better outcome.

10aCadmium10aMDA10aMorniga olifera extract.10aOxidative stress10aTestosterone1 aChatterjee, Pratik, Kumar1 aAnantharaya, Vinodini, Nithyanand1 aShiva, Rashmi, Kaup1 aKumar, Nayanatara, Arun1 aShetty, Sneha, Bhoja1 aBudihal, Suman, Veerappa1 aBhat, Mangalore, Ramesh1 a uhttp://fulltxt.org/article/185