02124nas a2200217 4500008004100000245013700041210006900178260001600247300001200263490000600275520140900281653001901690653002301709653002401732653001601756653002901772100002301801700002201824700002201846856003801868 2017 eng d00aAnti-hyperglycemic and Anti-hyperlipidemic Effects of Extract from Houttuynia cordata Thumb. in Streptozotocin-Induced Diabetic Rats0 aAntihyperglycemic and Antihyperlipidemic Effects of Extract from cApril 2017  a382-3870 v93 a

Aim: Various properties of Houttuynia cordata Thumb. has been reported. However, few studies on its pharmacological effects have been documented. To elucidate whether there are more pharmacological effects of this plant, this study was therefore, carried out to determine the anti-hyperglycemic and anti-hyperlipidemic effects of 80% ethanol extract of H. cordata (HCE). Their antioxidant activity and acute toxicity were also conducted. Methods: HCE at a dose of 250 mg/kg was oral given to Streptozotocin-induced diabetic rats daily for 8 weeks. DPPH assay and HCE at the doses of 1,000, 2,000 and 3,000 mg/kg were employed in antioxidant and acute toxicity studies. Results: HCE lowered FBG in the diabetic, but not in the normal treated rats. HCE did not affect the body weight of all rats, but recovered TP, Alb, Glob, BUN, CREA, UA, TB, AST, ALT, ALP, and reduced the elevated CHO, TG and LDL in the diabetic rats. HCE possessed relatively low antioxidant activity with IC50 of 115.98± 0.82 μg/mL compared to Vitamin C (42.54+1.37 μg/ml), but did not produce any symptoms of acute toxicity. Conclusions: The extract of H. cordata may have beneficial properties and is a new agent for diabetic treatment and improve renal and hepatic functions.

10aAcute toxicity10aAnti-Hyperglycemic10aAnti-Hyperlipidemic10aAntioxidant10aHouttuynia cordata Thumb1 aPoolsil, Patcharee1 aPromprom, Wilawan1 aTalubmook, Chusri u/files/PJ-9-3/10.5530pj.2017.3.65