02712nas a2200241 4500008004100000245019600041210006900237260001400306300001200320490000700332520187400339653002402213653002502237653002402262653002002286653002402306653001602330100001602346700002002362700002202382700002602404856004002430 2026 eng d00aThe Effectiveness of Enteral Administration of Binahong Leaf Extract (Anredera cordifolia (Tenore) Steenis) on Blood Glucose Levels, MDA, and NGF in Wistar Rats with Diabetic Neuropathy Model0 aEffectiveness of Enteral Administration of Binahong Leaf Extract cJune 2026 a107-1120 v183 a

Background: Chronic hyperglycemia causes oxidative stress in the peripheral nervous system, which leads to the development of diabetic neuropathy. Free radicals initiate lipid peroxidation of membranes and produce malondialdehyde (MDA). Reduced Nerve Growth Factor (NGF) in diabetes indicates significant neuronal abnormalities. Binahong (Anredera cordifolia (Ten.) Steenis) belongs to the Basellaceae family and possesses therapeutic effects, making it a promising herbal remedy for the development of treatments for diabetic neuropathy. Objective: To determine the effectiveness of binahong leaf extract (Anredera cordifolia (Tenore) Steenis) in lowering blood sugar and MDA levels and increasing NGF in Wistar rats with diabetic neuropathy. Methods: This study was an experimental study using rats with a randomized control trial with a post-test control only design. The study population consisted of 36 Wistar rats divided into 6 groups randomly, which were then induced with diabetic neuropathy via streptozotocin injection at 65 mg/kg. Complete data collection was conducted, followed by blood glucose levels, MDA, and NGF measurements, and data analysis. Results: There were significant differences (p<0.05) in blood glucose levels, MDA, and NGF between the normal group, the 50 mg/kg binahong leaf extract group, the 100 mg/ kg radish extract group, and the 200 mg/kg group compared to the negative control group. This indicates that binahong leaf extract, starting at a dose of 50 mg/kg, can reduce blood glucose levels and MDA while increasing NGF. Conclusion: Binahong leaf extract (Anredera cordifolia (Tenore) Steenis) is effective in lowering blood glucose levels and MDA levels while increasing NGF in a rat model of diabetic neuropathy.

10aAnredera cordifolia10ablood glucose levels10aDiabetic neuropathy10aMalondialdehyde10aNerve Growth Factor10aWistar Rats1 aFresia, Ana1 aRusip, Gusbakti1 aMukti, Ade, Indra1 aNasution, Ali, Napiah uhttps://www.phcogj.com/article/2598