02410nas a2200265   4500008004100000245012900041210007000170260001800240300001200258490000700270520162300277653000801900653001901908653000901927653002101936653001101957653002601968653001101994653001402005653000902019100003402028700002002062700002202082856004002104       2025                        eng d00aTherapeutic Effects of Combined Zinc and α-Tocopherol Administration in a Rat Model of Staphylococcus aureus-Induced Sepsis0 aTherapeutic Effects of Combined Zinc and αTocopherol Administrat  cDecember 2025  a275-2830 v173 a<p class="rtejustify">Sepsis induces systemic inflammation through excessive production of proinflammatory cytokines, leading to oxidative stress, tissue damage, and multiorgan dysfunction. This study aimed to evaluate the synergistic effects of combined zinc and vitamin E (α-tocopherol) supplementation on inflammatory and biochemical parameters in<em> Staphylococcus aureus</em>-induced sepsis in male Wistar rats. Thirty rats were divided into six groups: (1) normal control, (2) Placebo control (sepsis without therapy), (3) positive control (levofloxacin 45 mg/kg BW + zinc 0.9 mg/kg BW + vitamin E 250 mg/kg BW), and (4–6) treatment groups receiving combined zinc (0.9, 1.8, and 2.7 mg/kg BW) with vitamin E (250 mg/kg BW). Sepsis was induced intraperitoneally, followed by treatment according to group. On day 9, serum levels of TNF-α, IL-6, CRP, AST, ALT, urea, creatinine, and albumin were analyzed, while lung and kidney, were examined histologically. The combination of zinc and vitamin E significantly decreased TNF-α, IL-6, and CRP levels while improving biochemical parameters and increasing serum albumin compared to the untreated group (p ≤ 0.05). The highest efficacy was observed with zinc 2.7 mg/kg BW and vitamin E 250 mg/kg BW, which showed over 50% reduction in tissue damage, reduced inflammatory cell infiltration and interstitial hemorrhage in lung tissue, and improved hepatic cellular regeneration. These findings suggest that zinc and vitamin E exert synergistic anti-inflammatory and antioxidative effects, indicating their potential as adjuvant therapy in sepsis management.</p>
10aCRP10aHistopathology10aIL-610aOxidative stress10aSepsis10aStaphylococcus aureus10aTNF-α10aVitamin E10azinc1 aNapitupulu, Olivia, Des Vinca1 aRusip, Gusbakti1 aMutia, Maya, Sari  uhttps://www.phcogj.com/article/2568