02580nas a2200229 4500008004100000245016300041210006900204260001800273300001200291490000700303520182200310653002202132653001602154653001302170653001302183653002102196653001902217100002502236700001802261700003102279856004002310 2025 eng d00aUltrasonographic and Biochemical Evaluation of the Hepatoprotective Effect of Cinnamomum burmannii Bark Extract in Carbon Tetrachloride–Induced Liver Injury0 aUltrasonographic and Biochemical Evaluation of the Hepatoprotect cDecember 2025 a751-7590 v173 a

This study aimed to evaluate the hepatoprotective activity of ethanolic extract of cinnamon (Cinnamomum burmannii) in male Wistar rats induced with carbon tetrachloride (CCl). Cinnamon extract is known to contain bioactive compounds such as flavonoids and polyphenols, which play significant roles in antioxidant and anti-inflammatory mechanisms. Phytochemical analysis revealed that the extract contained total phenolic content of 71.55 mg GAE/g and flavonoid content of 0.41 mg QE/g, with a potent antioxidant activity indicated by an IC₅₀ value of 18.19 ppm. Administration of the extract for 28 days at a dose of 300 mg/kg body weight resulted in a significant reduction (P<0.05) in pro-inflammatory cytokines TNF-α, IL-6, and CRP levels compared to the negative control group. The 300 mg/kg dose showed the highest efficacy, with TNF-α levels approaching those of the normal group. Furthermore, liver function parameters improved, as evidenced by significant reductions in SGOT and SGPT enzyme levels, an increase in serum albumin (2.96 ± 0.52 g/dL), and a decrease in serum bilirubin to 0.102 ± 0.040 mg/dL. Ultrasonographic examination showed improved liver parenchymal homogeneity and a reduction in the number of nodules. Histopathological findings revealed a decrease in liver tissue damage score from moderate to mild. These findings suggest that Cinnamomum burmannii extract has potential hepatoprotective effects through antiinflammatory, antioxidant, and hepatocellular recovery mechanisms. Therefore, this extract holds promise as a phytopharmaceutical candidate for complementary therapy in liver function disorders; however, further studies are required to isolate the active compounds and evaluate long-term toxicity.

10aAnti-inflammatory10aAntioxidant10aCinnamon10aCytokine10aHepatoprotective10aHistopathology1 aMeilani, Inda, Kania1 aGirsang, Ermi1 aLubis, Yolanda, Eliza Putr uhttps://www.phcogj.com/article/2565