02261nas a2200205 4500008004100000245010300041210006900144260001900213300001200232490000700244520150000251653014201751100002101893700002101914700002801935700001501963700001901978700001801997856004002015 2025 eng d00aIntermittent Fasting as a Non-Invasive Strategy to Mitigate Diabetes-Induced Complications in Rats0 aIntermittent Fasting as a NonInvasive Strategy to Mitigate Diabe cSeptember 2025 a632-6370 v173 a

Introduction: The global burden of diabetes mellitus is steadily increasing. Abnormal eating patterns and excess energy intake contribute to obesity and type 2 diabetes mellitus (T2DM). Although dietary modifications such as intermittent fasting have gained attention, evidence supporting their beneficial role in T2DM is limited. Objective: To evaluate the beneficial effects of intermittent fasting on physiological, biochemical, and histological changes in a rat model of type 2 diabetes mellitus. Methods: Healthy adult Wistar albino rats (150–200 g) were used. Diabetes was induced by administering alloxan (150 mg/kg). Animals were divided into four groups: Normal Control (Group I), Experimental Control (Group II), and Intermittent Fasting groups (Group III & Group IV). Physiological, biochemical, and histological parameters were assessed to determine the impact of intermittent fasting. Results: Intermittent fasting demonstrated a protective effect by reducing diabetes-induced physiological, biochemical, and histological alterations. Rats in the intermittent fasting groups showed improved outcomes compared to the experimental control group. Conclusion: Intermittent fasting may serve as a potential non-invasive strategy to reduce diabetesrelated complications. Further studies focusing on molecular mechanisms are warranted to provide deeper insights into its protective role.

10aIntermittent fasting; Type 2 diabetes mellitus; Alloxan; Wistar rats; Physiological changes; Biochemical parameters; Histological changes1 aManchanda, Vishu1 aK, Bhagyalakshmi1 aKumar, Nayanatara, Arun1 aN, Anupama1 aKini, Rekha, D1 aShetty, Sneha uhttps://www.phcogj.com/article/2548