02510nas a2200253 4500008004100000245013600041210006900177260001900246300001200265490000700277520169800284653002001982653002802002653002402030653002102054100001802075700001902093700002802112700001702140700002102157700002102178700001702199856004002216 2025 eng d00aPotential Role of Ashwagandha [Withania Somnifera] As An Antioxidant On Aluminium Chloride-Induced Testicular Damage In Wistar Rats0 aPotential Role of Ashwagandha Withania Somnifera As An Antioxida cSeptember 2025 a583-5870 v173 a

Introduction: Aluminium is most prevalent and third most abundant element in earth crust after oxygen. Its exposure in high concentration can accumulate in many organs that damage various organs in living organisms like humans and animals. Although aluminum (Al) is known to induce oxidative damage through various mechanisms including binding to negatively charged phospholipids on the membrane of various tissue cell which are rich in PUFA.Hence,this study was aimed to find the potential role of ashwagandha on aluminum induced testicular toxicity. Methods: Animals were segregated into 4 groups of 6 rats in each. The control group, the Ashwagandha treated group, the Aluminum intoxicated group, pretreated with Ashwagandha with Aluminum intoxicity group. Testicular tissue was removed and were stored in 10% formalin saline and histopathological slides were done . A part of the tissues were processed for estimation of MDA and GSH level. Results: In the present study administration of aluminum in rats showed a significant decrease in the testicular tissue level of GSH and sperm count, as well as increase in the level of MDA and sperm morphology in aluminum treated group compared to normal control. Treatment with Ashwagandha showed a significant increase in testicular GSH level, sperm count and decrease in MDA level sperm morphology. Conclusion: The results of this study revealed that oral Aluminum Chloride administration induced adverse oxidative effects on the exposed animals and treatment with W. somnifera reduced the extent of aluminium chloride-induced tissue injury

10aMalondialdehyde10aReactive Oxygen Species10aReduced glutathione10aSperm morphology1 aBabu, Anchana1 aKini, Rekha, D1 aKumar, Nayanatara, Arun1 aGokul, Megha1 aK, Bhagyalakshmi1 aB, Sneha, Shetty1 aNA, Vinodini uhttps://www.phcogj.com/article/2541