03177nas a2200289 4500008004100000245011600041210006900157260001600226300001200242490000700254520227100261653001502532653001502547653001802562653002402580653002402604653002102628100002102649700002402670700001702694700001802711700002102729700003402750700003002784700003302814856004002847 2025 eng d00aA Comprehensive Review on the Pharmacological Potential of Dioscorea bulbifera and its Potential Hepatotoxicity0 aComprehensive Review on the Pharmacological Potential of Dioscor cAugust 2025 a520-5300 v173 a

Dioscorea bulbifera, or the air potato has been studied and used in traditional medicine for centuries particularly in countries like China and India. It is loaded in different secondary metabolites such as steroidal saponins, flavonoids, diterpenoids, tannins, and carotenoids, which all play a major role in its pharmacological activities. Researchers have shown that it can be useful in the treatment of inflammation, microbial infections, oxidative stress, cancer, and liver diseases. even with these benefits there remains a shortage of clinical trials, toxicity assessment, and standardized extraction procedures to facilitate its application in herbal drug industry in a safe manner. One of the most striking features of Dioscorea bulbifera is its antimicrobial activity especially in the fight against antibiotic-resistant bacteria. also, studies done on anticancer activity are actively being conducted with some compounds being reported to induce apoptosis in cancer cells and suppress the growth of tumour. However, talking about its drawbacks some diterpenoid compounds such as diosbulbin A have been reported to show hepatotoxicity in humans and hence further studies are required to determine its safety for therapeutic purposes. The other significant challenge to developing this plant as a standard drug is its variability in chemical composition. The bioactive content is dependent on its cultivation, so it is quite a challenge to control for consistent potency. Sophisticated analytical methods such as HPLC and LC-MS could be utilized to overcome this and contemporary drug delivery systems like nano-formulations could enhance its absorption and bioavailability. Bringing together the ancient herbal knowledge and new scientific inquiry might reveal even greater therapeutic applications of the plant constituents. In the future the studies need to penetrate deeply into its safety, carry out extensive clinical trials, and explore sustainable mechanisms for massproducing its major compounds. With additional studies, Dioscorea bulbifera could become a prominent natural medicine, providing solutions for numerous health conditions while maintaining its traditional medicinal significance.

10aair potato10aAnticancer10aAntimicrobial10aBioactive compounds10aDioscorea bulbifera10aMedicinal plants1 aAdarkar, Rudresh1 aS, Chandrashekar, K1 aPai, Vasudev1 aLobo, Richard1 aN, Aswatharam, H1 aTippavajhala, Vamshi, Krishna1 aD’Souza, Ullas, Prakash1 aShankara, Rajesh, Kaverikana uhttps://www.phcogj.com/article/2531