02195nas a2200253 4500008004100000245013300041210006900174260001600243300001200259490000700271520139100278653001401669653002501683653001801708653001801726100001901744700002601763700001901789700002301808700002501831700002301856700002201879856004001901 2025 eng d00aFormulation and Analytical Evaluation of Herbal Rectal Suppositories Containing Senna Extract for the Management of Constipation0 aFormulation and Analytical Evaluation of Herbal Rectal Supposito cAugust 2025 a438-4430 v173 a

Background. Senna is a commonly used stimulant laxative that is typically administered orally as a senna extract tablet to treat constipation. This study aimed to formulate rectal suppositories containing senna extract, using glycerin as a base, to achieve site-specific drug delivery and reduce systemic side effects. Methodology. The prepared suppositories were evaluated for various physicochemical and performance parameters, including visual appearance, disintegration time, in vitro dissolution, melting point, weight uniformity, drug content and HPTLC. Results. The suppositories demonstrated satisfactory physical characteristics, with an average weight of 0.9707 g and a drug content of 0.150 ± 2% mg per suppository. The melting point was recorded at 37°C, and the complete dispersion time was 30 minutes. In vitro drug release studies revealed that the drug was fully released within 45 minutes. High-performance thin layer chromatography (HPTLC) was utilized to confirm the presence of active constituents by comparing the sample profile with that of a standard extract. Conclusion. These findings suggest that senna extract suppositories are a promising alternative to oral tablets, providing targeted drug delivery through the rectal route for improved therapeutic outcomes.

10aGlycerine10aherbal suppositories10asenna extract10asuppositories1 aDutta, Abhinav1 aPrasad, Jyothi, Sujan1 aAnand, Pradyum1 aK.S, Chandrashekar1 aB, Venkatesh, Kamath1 aK, Vijaya, Bhaskar1 aH.N, Aswatha, Ram uhttps://www.phcogj.com/article/2521