01973nas a2200205 4500008004100000245006900041210006500110260001700175300001200192490000700204520136700211653002201578653001501600653001601615653001901631653001801650100003001668700002901698856004001727 2025 eng d00aA Review: Searsia genus and Its Potential Anti-Cancer Properties0 aReview Searsia genus and Its Potential AntiCancer Properties cJanuary 2025 a117-1200 v173 a

The Searsia genus, belonging to the Anacardiaceae family, comprises small trees and evergreen shrubs primarily found in Southern Africa, with some species extending to East Africa and the Mediterranean. While these species are well-known for their ecological roles in stabilizing soils and providing habitat for wildlife, they also possess significant medicinal value, particularly in traditional African medicine. Searsia plants are rich in bioactive compounds such as flavonoids, phenolic acids, and tannins, which exhibit potent anti-inflammatory, antibacterial, antioxidant, and anticancer properties. This has drawn scientific interest, especially regarding their potential in cancer treatment. Notably, Searsia chirindensis and other species have demonstrated cytotoxic effects against various cancer cell lines, attributed to compounds like gallic acid and other polyphenolics. This review delves into the phytochemical profiles of selected Searsia species, exploring their medicinal properties with a particular focus on their anticancer activities. The anti-inflammatory properties of these plants, coupled with their antioxidant activities, suggest a promising role in cancer prevention and treatment, although further research is necessary to confirm these benefits in clinical settings.

10aAnti-inflammatory10aAnticancer10aAntioxidant10aPhytochemistry10aSearsia genus1 aRampana, Dijeng, Euginiah1 aMakhoahle, Pakiso, Moses uhttps://www.phcogj.com/article/2479