02074nas a2200265 4500008004100000245010900041210006900150260001800219300001400237490000700251520116800258653001901426653001601445653001501461653001801476653001801494100003901512700003501551700003501586700003801621700004001659700003801699700003101737856004001768 2024 eng d00aAntidepressant, Anxiolytic, and Antioxidant Properties of Piper Aduncum Essential Oil from Northern Peru0 aAntidepressant Anxiolytic and Antioxidant Properties of Piper Ad cDecember 2024 a1252-12580 v163 a

This investigation aimed to evaluate the antidepressant, anxiolytic, and antioxidant effects of Piper aduncum essential oil from northern Peru. The essential oils were obtained through hydro-distillation using a modified Clevenger-type apparatus. The chromatography-mass spectrometry (GC-MS) was used to assess the chemical composition. Behavioral assays in mice were used to evaluate the antidepressant and anxiolytic effects. In addition, the antioxidant capacity was performed through DPPH, ABTS, and FRAP assays. The GC-MS analysis revealed that linalool (29.16%), bicyclogermacrene (13.32%), nerolidol (12.38%), and β-caryophyllene (10.76%) were the principal components. The results demonstrated significant antidepressant and anxiolytic effects comparable to fluoxetine and diazepam, with statistical differences between all groups (p<0.005). The IC50 values for the DPPH, ABTS, and FRAP assays were 5.9±0.08, 0.20±0.06, and 109.5±1.3, respectively. Consequently, Piper aduncum essential oil exhibits antidepressant and anxiolytic-like effects and modest antioxidant properties compared to the controls.

10aAntidepressant10aAntioxidant10aAnxiolytic10aEssential oil10aPiper aduncum1 aAlvarado-García, Paul, Alan Arkin1 aSoto-Vásquez, Marilú, Roxana1 aJara-Aguilar, Demetrio, Rafael1 aGavidia-Valencia, José, Gilberto1 aGuzmán-Rodríguez, Natalia, Mavila1 aRodrigo-Villanueva, Elda, Maritza1 aBeltrán, Iris, Melina Alf uhttps://www.phcogj.com/article/2417