01817nas a2200205   4500008004100000245011800041210006900159260001700228300001400245490000700259520119200266653002701458653000801485653001001493653000801503653000801511100002801519700002401547856004001571       2024                        eng d00aCiplukan Fruit Extract (Physalis angulata L.) on IL-12 and Oxidative Stress in Mice Gestational Diabetes Mellitus0 aCiplukan Fruit Extract Physalis angulata L on IL12 and Oxidative  cOctober 2024  a1121-11230 v163 a<p class="rtejustify">Gestational diabetes mellitus (GDM) is a common pregnancy complication, characterized by increased blood glucose levels that occur during pregnancy. Oxidative stress in hyperglycemia increases the inflammatory response in GDM by stimulating pro-inflammatory genes. IL-12 is a pro-inflammatory cytokine that is generally involved in inflammatory responses . This research aims to determine the effect of ciplukan fruit extract against IL-12, and Oxidative Stress in Gestational Diabetes Mellitus mice . The method used in this research is RAL (Completely Randomized Design). Analysis of cytokine levels using the ELISA reading method was followed by data analysis using the ANOVA test . The results showed that the treatment given gradually increased the highest cytokine levels in the P4 group showing the highest increase with IL-12 levels of 0.246 pg/mL, SOD of 0.160 U/mg protein, and MDA of 0.070 μmol/L. In this study it can be concluded that the P4 group showed the strongest effect in all parameters, indicating the potential of the agent or intervention as an immunomodulator and antioxidant, although it requires good management of oxidative stress.</p>
10aCiplukan fruit extract10aDMG10aIL-1210aMDA10aSOD1 aGondo, Harry, Kurniawan1 aHaryanti, Elizabeth  uhttps://www.phcogj.com/article/2393