02280nas a2200229 4500008004100000245012600041210006900167260001700236300001500253490000700268520152900275653002201804653002301826653001001849653001401859653002901873100002201902700003101924700003101955700002401986856004002010 2024 eng d00aAssociation of Triglyceride and Glucose Index with Non-Alcoholic Fatty Liver Disease in Type 2 Diabetes Mellitus Patients0 aAssociation of Triglyceride and Glucose Index with NonAlcoholic  cOctober 2024 a1077- 10800 v163 a

Introduction: Non-alcoholic fatty liver disease (NAFLD) is significantly linked to obesity, insulin resistance (IR), metabolic syndrome, and type 2 diabetes (T2DM). There isn't a single biomarker used to diagnose NAFLD. Objectives: Analyzing the association between triglyceride and glucose index (TyG) with NAFLD in T2DM. Methods: This cross-sectional study aimed to assess the efficacy of TyG as a potential NAFLD biomarker. The study was conducted on 103 diabetes outpatient clinics at the Dr. Soetomo General Academic Hospital from August to October 2023. Sixty-seven subjects experienced steatosis, while those who did not experience steatosis were 36. The statistical analysis used in this study is binary logistic regression with p <0.05. Results: The receiver operating characteristic curves (ROC) analysis showed a TyG cut-off value of 9.334 (AUC = 0.660). Analysis of the risk of TyG on the incidence of steatosis was carried out using binary logistic regression. The results showed that TyG was a significant risk factor for steatosis. Patients with a TyG value above 9.334 risk developing steatosis 3.567 times greater than patients with a TyG value below 9.334 (OR 95% = 1.373 – 9.270, p = 0.009). Conclusion: A significant association between TyG and NAFLD in T2DM patients, which the TyG index may be a more effective, valuable, and uncomplicated measure for detecting and controlling NAFLD.

10aHepatic steatosis10aInsulin resistance10aNAFLD10aTyG index10aType 2 diabetes mellitus1 aKurniawati, Febri1 aMudjanarko, Sony, Wibisono1 aSoelistijo, Soebagijo, Adi1 aSugihartono, Titong uhttps://www.phcogj.com/article/2386