02222nas a2200241   4500008004100000245013500041210006900176260001700245300001400262490000700276520140700283653001801690653002401708653002201732653003301754653001601787100002001803700002501823700003301848700002801881700003101909856004001940       2024                        eng d00aHyperbaric Oxygen in Animal Model of Diabetes Nephropathy: Analysis of Blood Glucose, Proteinuria and Kidney Tissue Necrosis Cells0 aHyperbaric Oxygen in Animal Model of Diabetes Nephropathy Analys  cOctober 2024  a1043-10460 v163 a<p class="rtejustify">Diabetic nephropathy (DN) is a microvascular complication of diabetes mellitus (DM) and is the main cause of 20 to 40 times higher mortality compared to diabetes without nephropathy. Therefore, the author wants to prove the effect of hyperbaric oxygen therapy (HBO) on changes in blood glucose levels, proteinuria and kidney tissue necrosis cells in DN animal models. This study used 27 male white rats Rattus Norvegicus strain Wistar, weighing 170 - 220 grams, aged 8-12 weeks, healthy and active, divided into 3 groups, namely the normal rats group (G0), the DN rats without HBO group (G1) and the DN rats with HBO group (G2). Making a DN model with Streptozotocin (STZ) induction 75 mg / kgBW intraperitoneally in a single dose. HBO was performed in a 2.4 ATA pressurized air chamber by inhaling 98% O2 for 3 x 30 minutes interspersed with inhaling normal air for 2 x 5 minutes for 5 consecutive days. The results showed a significant decrease in blood glucose levels p = 0.000 (p &lt;0.05). In proteinuria levels, there was an insignificant decrease p = 0.077 (p &gt; 0.05) in G2 compared to G1. Repair of kidney tissue damage was also indicated by a decrease in necrotic cells by 45.45% in G2 compared to G1. These results prove that HBO can repair kidney damage in DN model mice, so HBO is expected to be used as an additional therapy in cases of diabetic nephropathy.</p>
10aBlood glucose10aDiabetes Nephropaty10aHyperbaric Oxygen10aKidney Tissue Necrosis Cells10aProteinuria1 aHarnanik, Titut1 aSudiarta, Ketut, Edy1 aNapitupulu, Rudi, Pandapotan1 aNurdianto, Arif, Rahman1 aDarmayanti, Ni, Ketut Alit  uhttps://www.phcogj.com/article/2380