02537nas a2200217 4500008004100000024000700041245011800048210006900166260001600235300001200251490000700263520183800270653002902108653002502137653002602162653002902188100002202217700001902239700002102258856004002279 2024 eng d a3100aPhytochemical Screening, Antioxidant and Anti-Arthritis Potential of Decoction Extract from Caulerpa lentillifera0 aPhytochemical Screening Antioxidant and AntiArthritis Potential  cAugust 2024 a927-9320 v163 a

Caulerpa lentillifera also known as sea grape, is a green seaweed in the Caulerpaceae family known for its nutritional benefits and medicinal properties. This study aimed to examine the phytochemical compounds, total phenolic content, total flavonoid content, and antioxidant and anti-arthritis properties of sea grape decoction extract. The total phenolic content was measured using the Folin-Ciocalteu method, and the total flavonoid content was determined with the aluminum chloride colorimetric method. Antioxidant activities were evaluated using two methods: 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2’-azinobis-(3- ethylbenzothia-zoline-6-sulfonate) (ABTS). The anti-arthritis activities were assessed using bovine-serum protein. The study identified that the extract contained flavonoids, saponin, terpenoids and coumarins, with the total phenolic content of 343.19 ± 9.86 μg gallic acid equivalents/ mg dry extract and the total flavonoid content of 268.48 ± 16.57 μg quercetin equivalents/ mg dry extract. The extract showed antioxidant activity with an IC50 value of 309.05±5.91 μg/ml using the DPPH method and 572.33±3.47 μg/ml using the ABTS method, respectively. Additionally, it exhibited anti-arthritis properties with an IC50 value of 54.60±12.71 μg/ml, which was less than 1.69 times the IC50 value of diclofenac sodium. A strong positive correlation was found between the antioxidant and anti-arthritis activities measured by the ABTS method, with an R² value of 0.9476. Therefore, this study provides initial evidence supporting the antioxidant and anti-arthritis activities of sea grape decoction extract. The extract shows potential for further development as a product for treating arthritis.

10aAnti-arthritis activity.10aantioxidant activity10aCaulerpa lentillifera10aPhytochemical components1 aJarmkom, Khemjira1 aEiamart, Wanna1 aTunit, Prakairat uhttps://www.phcogj.com/article/2360