01952nas a2200217 4500008004100000245007000041210006900111260001800180300001200198490000600210520131000216653001701526653002101543653001001564653001701574653002601591653002701617100003001644700002101674856003901695 2017 eng d00aAnti-HIV Activity of Phytosterol Isolated from Aerva lanata Roots0 aAntiHIV Activity of Phytosterol Isolated from Aerva lanata Roots cNovember 2016 a112-1160 v93 a

Background: AIDS in humans, which is caused by the HIV remains among the leading causes of death worldwide. Objective: The study was undertaken to investigate the HIV-RT inhibitory activity of Phytotesrols extracted from roots of Aerva lanata. Methodology: Sequential maceration method was performed for preparation of extracts using hexane, chloroform, ethyl acetate, acetone and methanol solvents. RetroSys HIV-1 RT (Innovagen, Sweden) kit was used to determine the HIV-RT inhibitory activity of all solvents extracts. Results & Discussion: All extracts showed significant inhibitory activity. Chloroform extracts shows highest inhibition of recombinant HIV-RT (89.0%) at 2 and mg/ml concentration. Phytosterols isolated from chloroform extracts. These results were remarkable and can be used to develop a new drug for HIV treatment or other infectious diseases caused by the pathogenic micro-organisms, for which plant sterols may play a distinctive role. Conclusion: Further work is in progress to evaluate the advanced spectroscopic studies are required for the structural elucidation, identification and characterization of the active compound from this plant.

10aAerva lanata10aCharacterization10aHIV-110aPhytosterols10aReverse transcriptase10aStructural elucidation1 aGujjeti, Rajendra, Prasad1 aMamidala, Estari uhttps://www.phcogj.com/article/236