02733nas a2200253 4500008004100000245017300041210006900214260001400283300001200297490000700309520184900316653001402165653001802179653002002197653001902217100003202236700002202268700003402290700003302324700002702357700003202384700002302416856004002439 2024 eng d00aPhytochemistry, Antihyperglycemic, Antioxidant and Anti- Inflammatory Properties of Uvaria Chamae and Sida Linifolia Extracts: Potential Implication in Diabetic Disease0 aPhytochemistry Antihyperglycemic Antioxidant and Anti Inflammato cJune 2024 a582-5900 v163 a

Introduction: Uvaria chamae and Sida linifolia are plants traditionally used in Togo in diabetes treatment, an affection that often leads to several complications. This study aimed to evaluate the antihyperglycemic, anti-inflammatory, antioxidant activity and toxicity of these two plants extracts. Methods: A phytochemical analysis was carried out on extracts obtained either by decoction or maceration in ethanol of Uvaria chamae leaves and Sida linifolia whole plant. Evaluation of the antihyperglycemic activity consisted in glucose absorption test using yeast and rats’ muscle and jejunum. DPPH test, total antioxidant capacity assay, hemolysis and egg albumin denaturation inhibition assays and evaluation of extracts acute toxicity were performed. Results: Hydroalcoholic extract of Uvaria chamae showed the strongest antihyperglycemic activity (p<0.05); the highest phenolic contents (147.93 ± 1.01 mg/g), the best total antioxidant capacity (153.33 ± 4.07), the lowest IC50 (μg/mL) for DPPH test (296.96 ± 91.69), a capacity of hemolysis (825.99 ± 29.24) and egg albumin denaturation (738.10 ± 92.26) inhibition assays. In the same way, hydroalcoholic extract of Sida linifolia, showed the strongest antihyperglycemic activity (p<0.05), the highest phenolic contents (71.60 ± 2.16 mg/g), the best total antioxidant capacity (146.98 ± 2.81), lowest IC50 (μg/ mL) for DPPH test (788.28 ± 112.54), the hemolysis (882.03 ± 20.86) and egg albumin denaturation (1966.18 ± 35.94) inhibition assays. None of the extracts showed acute toxicity in rats. Conclusion: the hydroalcoholic leaves extract of Uvaria chamae and of the whole plant of Sida linifolia could be candidates in the treatment of diabetes and its complications.

10aDecoction10ahyperglycemia10aNeuroprotection10aPhytochemistry1 aSanvee, Sabrina, Chris Jani1 aKombate, Bignoate1 aKantati, Yendubé, Tougheligh1 aKpoyizoun, Pascaline, Kindji1 aBadjabaissi, Essotolom1 aDiallo, Mindede, Assih1 Abo1 aBakoma, Batomayena uhttps://www.phcogj.com/article/2297