02003nas a2200217   4500008004100000245009700041210006900138260001500207300001200222490000700234520131100241653002201552653002801574653001401602653001801616100002401634700003101658700002301689700003301712856004001745       2024                        eng d00aVitamin D and Wound Recovery: Illuminating the Path to Enhanced Healing in Diabetic Patients0 aVitamin D and Wound Recovery Illuminating the Path to Enhanced H  cApril 2024  a485-4910 v163 a<p class="rtejustify">Wound healing is a highly coordinated biological event as a response to injured skin. It commonly takes 14 days for a wound to be completely healed. However, the duration of wound healing may vary between individuals due to certain factors. One major factor that delays the wound-healing process is Diabetes Mellitus. Delayed wound healing with poor prognosis commonly occurs in diabetic patients. Chronic hyperglycemia may affect macrophage polarisation, which is essential in the wound healing mechanism. The macrophage polarisation enables the pro-inflammatory M1 phenotype to switch to the anti-inflammatory M2 phenotype. Thus, pro-inflammatory M1 phenotype prevails persistently in diabetic wounds, while the anti-inflammatory M2 phenotype remains deficient. It results in significantly elevated levels of pro-inflammatory cytokines triggered by the M1 phenotype. Prolonged wound healing times increase the risk of infection, which can lead to more severe complications. Vitamin D is widely recognized for its essential role in regulating calcium levels and supporting bone health, as well as its positive effects on the immune system. This vitamin has the potential to skew macrophages towards the M2 phenotype and promote a regenerative and anti-inflammatory environment.</p>
10aDiabetes mellitus10aMacrophage Polarisation10aVitamin D10aWound Healing1 aChrisdianto, Aditya1 aAirlangga, Prananda, Surya1 aWirabuana, Belindo1 aIskandar, Regina, Purnama De  uhttps://www.phcogj.com/article/2278