02731nas a2200289 4500008004100000245020300041210006900244260001500313300001200328490000700340520173700347653003702084653002502121653002802146653002102174653001002195653001302205653002702218100002802245700003102273700003302304700002802337700000502365700002602370700000502396856004002401 2024 eng d00aThe Role of Neuron Specific Enolase, S100B, Glial Fibrillary Acidic Protein, and Myelin Basic Protein as Prognostic and Survival Values in Traumatic Brain Injury: Systematic Review and Meta-analysis0 aRole of Neuron Specific Enolase S100B Glial Fibrillary Acidic Pr cApril 2024 a478-4840 v163 a

Background: The high number of accidents and traumatic brain injuries, especially in the productive age group, causes a lot of morbidity and mortality. A fast and accurate examination method is needed for the diagnosis and treatment of traumatic brain injury. Nerve damage biomarkers such as Neuron Specific Enolase, S100B, Glial Fibrillary Acidic Protein, and Myelin Basic Protein, have been used globally both for research and daily use to determine the severity of traumatic brain injury. Methods: Searches and journal searches were carried out from Science Direct, Scopus, Springer Link, and PubMed, with the keywords "Neuron Specific Enolase", "S100B", "Glial Fibrillary Acidic Protein", "Myelin Basic Protein", and "Traumatic Brain Injury ”. Screening was carried out using PRISMA 2021 to look for studies that met the criteria and were of sufficient study quality according to the Newcastle-Ottawa Scale. Results: Twenty-three studies were collected and further grouped based on outcomes, both prognostic and survival outcomes. Neuron Specific Enolase, S100B, and Glial Fibrillary Acidic Protein values were higher in poor outcomes (all p values < 0.001) and poor survival (all p values < 0.001) in traumatic brain injury. Myelin Basic Protein was not significant in poor outcome (p = 0.35), but was higher in poor survival (p < 0.001) in traumatic brain injury. Conclusion: Neuron Specific Enolase, S100B, and Glial Fibrillary Acidic Protein, can be used as markers for prognostic and survival value in traumatic brain injury. Myelin Basic Protein can be used as a marker for survival value in traumatic brain injury.

10aGlial Fibriallary Acidic Protein10aMyelin Basic Protein10aNeuron Specific Enolase10aPrognostic Value10aS100B10aSurvival10aTraumatic Brain Injury1 aSutrisno, Wibowo, Artho1 aAirlangga, Prananda, Surya1 aWungu, Citrawati, Dyah Kenco1 aKriswidyatomo, Prihatma1 a1 aSemedi, Bambang, Pujo1 a uhttps://www.phcogj.com/article/2277