02676nas a2200325 4500008004100000245009000041210006900131260001500200300001200215490000700227520161700234653001001851653001801861653002101879653000901900653001801909100003801927700002801965700002801993700003302021700004202054700003202096700002702128700003002155700003502185700003002220700003202250700002802282856004002310 2024 eng d00aWound Healing Activity of an Essential Oil-Based Cream of Origanum vulgare L. on Mice0 aWound Healing Activity of an Essential OilBased Cream of Origanu cApril 2024 a292-2950 v163 a

Background and Aim: The objective was to evaluate the effect of a cream based on the essential oil of Origanum vulgare on skin lesions induced in Mus musculus Balb/c. Materials and Methods: The experimental animals were divided into four groups of 6 specimens each, in which skin lesions of approximately 1 cm in diameter were induced. Group I (Control) received no treatment, Group II (0.1% Origanum vulgare cream), Group III (0.5% Origanum vulgare cream), and Group IV (1% Origanum vulgare cream) received treatment for eight days. Skin lesions were measured on days 4 and 7. At the end of treatment, they were euthanized using sodium pentobarbital 60 m/kg v.ip. Skin samples were obtained and preserved in 10% formalin for histopathological analysis. Results: When measuring the size of the skin lesions induced in the study groups, it was observed that in the control group, the decrease in the length of the lesions occurred on the fifth day; in group II, III, and IV, the lesions length decrease occurs on the second day. At the end of the experience, the measurements of the lesions were much smaller for the III and IV groups (0.33 and 0.41, respectively) compared to the control group (0.40 cm). On day seven, statistically significant difference was found on skin lesion measure between Group IV and the Control, with a significance level of p<0.05. Conclusion: It is concluded that the 1% Origanum vulgare essential oil-based cream has a healing effect on dermal lesions induced in Mus musculus Balb/c.

10aCream10aEssential oil10aOriganum vulgare10aSkin10aWound Healing1 aG, Laurente-Pachamango, Katherine1 aL, Cruzado-Razco, José1 aR, Silva-Correa, Carmen1 aE, Villarreal-La, Torre Víc1 aAntonio, Sagástegui-Guarniz, William1 aD, Gamarra-Sánchez, César1 aGomez-Arce, Ricardo, M1 aDionicio-Rosado, Deivy, Y1 aCastañeda-Carranza, Julio, A.1 aA, Calderón-Peña, Abhel1 aL, Aspajo-Villalaz, Cinthya1 aE, Chávez-, Flores Jua uhttps://www.phcogj.com/article/2245