01928nas a2200241 4500008004100000245008100041210006900122260001800191300001000209490000600219520124100225653002001466653002601486653000801512653001901520653000801539100002101547700001701568700001601585700001901601700002701620856003901647 2017 eng d00aThe Serum Protein Fractions in Streptozotocin (STZ) Administrated Rat Models0 aSerum Protein Fractions in Streptozotocin STZ Administrated Rat  cDecember 2016 a35-380 v93 a

Background: Experimental diabetes can be induced using chemical agents such as streptozotocin. Objective: This study aimed to investigate the effect of streptozotocin (STZ) which is most important agent to produce experimental diabetic model at two different doses on serum protein fractions in rat models. Materials and Methods: Twenty-four male rats that weighed an average of 250 g and were 3–4 months old were used as the experimental models. They were sorted into three groups composed of eight rats each of STZ 55 mg/kg, STZ 65 mg/kg and control. Diabetes was induced by administering STZ 55 mg/kg and 65 mg/kg intraperitoneally. The serum protein fractions were analyzed by cellulose acetate electrophoresis. Results: No significant difference was observed between the groups for all fractions except alpha-2 and beta globulins. The alpha-2 and beta globulin levels were significantly higher in the 55 mg/kg group than in the 65 mg/kg STZ and control groups (p<0.05). Conclusion: This increase may be due to the involvement of different proteins in the alpha-2 and beta globulin protein fractions.

10aelectrophoresis10aexperimental diabetes10aRat10aserum proteins10aSTZ1 aRagbetli, Cennet1 aDede, Semiha1 aKoc, Feride1 aYuksek, Veysel1 aRagbetli, Murat, Cetin uhttps://www.phcogj.com/article/223