02191nas a2200193 4500008004100000245008500041210006900126260001800195300001200213490000700225520160000232653001701832653002101849653001601870100002601886700002301912700002201935856004001957 2024 eng d00aNew Insights of Oxidative Stress and Thalassemia May Lead to Antioxidant Therapy0 aNew Insights of Oxidative Stress and Thalassemia May Lead to Ant cFebruary 2024 a202-2040 v163 a

Background: Because of chronic hemolysis, thalassemic patients are under oxidative cell injury caused by secondary iron overload. This provokes oxidative damage to the cellular membranes of organs that accumulate excess iron. Several researchers studied the oxidative stress in patients with thalassemia during chelation therapy and repeated blood transfusion periods, and they found that β-thalassemia patients are under oxidative stress, but they did not focus on before the chelating therapy period. Objective: To evaluate the total antioxidant capacity (TAOC) and oxidative stress (OS) in newly diagnosed patients with β-thalassemia before chelating therapy. Methodology: In the present case-control study, twenty patients newly diagnosed with β-thalassemia before receiving chelating agents, and another 30 healthy individuals, sex-matched with patients, considered as a control, were included in the study. Total antioxidant capacity (TAOC) and Malondialdehyde (MDA) were assessed in the studied groups. Results: The TAOC values of the thalassemic group (35±0.11 u/ml ) were significantly (p<0.001) lower than that of the control group (79±7.2 u/ml). MDA values of the thalassemic group (7.9 ±2.35nmol/l) were significantly (p<0.001) more than that of the control group (0.57±0.25 nmol/l). Conclusion: The present study demonstrated that patients with β thalassemia have decreased values of TAOC, and increased values of MDA when compared with the control group.

10aAntioxidants10aOxidative stress10aThalassemia1 aNeaimy, Kassim, SA Al1 aAlkhyatt, Maes, MK1 aJarjess, Israa, A uhttps://www.phcogj.com/article/2229