02364nas a2200241   4500008004100000245012700041210006900168260001800237300001200255490000700267520157000274100002801844700001601872700002801888700002901916700002401945700002101969700001701990700002302007700002202030700003002052856004002082       2024                        eng d00aEffect of Lactiplantibacillus plantarum IS-10506 on Accelerating Repair of Ketorolac-Induced Gastric Ulcers in Wistar Rats0 aEffect of Lactiplantibacillus plantarum IS10506 on Accelerating   cFebruary 2024  a181-1850 v163 a<p class="rtejustify">A gastric ulcer arises due to an imbalance between the stomach's aggressive and defensive factors, one of which can be induced by ketorolac. The gastric mucosa serves as a protective layer against gastric damage. Probiotics may enhance mucosal secretion, reinforcing their barrier function. This study evaluated the effect of Lactiplantibacillus plantarum IS-10506 on repairing gastric mucosal injury expressed by Mucin 5AC (MUC5AC) induction from ketorolac in rodent model. In the experiment, 48 male Wistar rats were randomly assigned and segregated into four groups: the control group (K1), the group with ketorolac administration (K2), the group given L. plantarum IS-10506 after ketorolac administration (K3), and the group given L. plantarum IS-10506 before and after ketorolac administration (K4). Gastric tissue was examined for cells producing MUC5AC via immunohistochemistry. MUC5AC differences between groups were compared using Kruskal–Wallis and Mann–Whitney U tests. Significant differences were observed between each group on Days 5, 7, and 10 of necropsy (p=0.043; p=0.030; p=0.022). The ketorolac group (K2) consistently exhibited the lowest values during all examination days. Group K4 manifested a higher expression of MUC5AC relative to group K3. However, group K3 demonstrated a significantly increased from Day 1 to 10 of necropsy (p=0.030). Administering probiotic L. plantarum IS-10506 prior to ketorolac proved beneficial by significantly accelerate (p=0.030) the MUC5AC expression cells and gene expression.</p>
1 aAndarsini, Mia, Ratwita1 aDarma, Andy1 aAthiyyah, Alpha, Fardah1 aSumitro, Khadijah, Rizky1 aRanuh, Reza, Gunadi1 aPratiwi, Fauziah1 aRiawan, Wibi1 aWidjiati, Widjiati1 aSurono, Ingrid, S1 aSudarmo, Subijanto, Marto  uhttps://www.phcogj.com/article/2226