02267nas a2200289   4500008004100000245017100041210006900212260001800281300001400299490000700313520131000320653002801630653001501658653001501673653002901688653002601717653002101743100002601764700002901790700002501819700001901844700001901863700001601882700002001898700001901918856004001937       2023                        eng d00aThe Effect of Ramania Leaves Extract Gel (Bouea macrophylla  Griff) on the Number of Osteoblast (in vivo Study of Post  Extraction in Wistar Rats (Rattus norvegicus))0 aEffect of Ramania Leaves Extract Gel Bouea macrophylla Griff on   cDecember 2023  a1219-12230 v153 a<p class="rtejustify">Ramania leaves extract contains secondary metabolite compounds such as flavonoids, steroids, phenols and terpenoids which can be used as an alternative medicine for socket wound healing. Flavonoids have anti-inflammatory and antioxidant properties that can accelerate wound healing and can stimulate the formation of osteoblasts. Analyzing the differences in the number of osteoblasts in the negative control group, positive control given aloe vera gel 15% and ramania leaf extract gel 15% on day 5, 7 and 14. This study used true experimental design with posttest-only control design, using 27 rats divide into 3 groups. The experimental animals were sacrificed on days 5, 7 and 14 for histopathological observations. Two-Way ANOVA test results obtained p value = 0.013 &lt;0.05, which indicates that there is a significant difference between the use of 15% ramania leaf extract gel 15% and the number of osteoblasts on days 5, 7 and 14. Bonferroni's Post Hoc test showed a difference. The number of osteoblasts was significant among the negative control group with ramania leaf extract gel 15%. Ramania leaf extract gel 15% was proven to be able to increase the number of osteoblasts and has the potential as an alternative medicine for socket healing after tooth extraction.</p>
10aBouea macrophylla Griff10aFlavonoids10aOsteoblast10aRamania leaf extract gel10aSecondary  metabolite10aTooth extraction1 aTaufiqurrahman, Irham1 aGupita, Siti, Hajar Norm1 aOktiani, Beta, Widya1 aErlita, Isyana1 aZulkifli, Andi1 aHadju, Veni1 aMallongi, Anwar1 aSuhartono, Eko  uhttps://www.phcogj.com/article/2198