01939nas a2200217 4500008004100000024000700041245017400048210006900222260001700291300001200308490000700320520121100327653001001538653003601548653001101584100001801595700001901613700002701632700002201659856004001681 2023 eng d a3200aThe Analysis of Matrix Metalloproteinase-9 and Tissue Inhibitor Matrix Metalloproteinase-1 Levels in the Amniochorion Membrane Patients on Premature Rupture of Membranes0 aAnalysis of Matrix Metalloproteinase9 and Tissue Inhibitor Matri cOctober 2023 a910-9120 v153 a

Introduction: MMP-9 is essential for extracellular matrix remodeling, which affects the incidence of premature rupture of membranes. In addition, decreased and increased levels of TIMP-1, a preferential MMP-9 inhibitor, have been reported to be associated with premature rupture of membranes because it showed an imbalance in the MMP-9 or TIMP-1 levels. This study aims to analyze MMP-9 and TIMP-1 levels in amniochorion membrane patients on premature rupture of membranes. Methods: An analytic observational study was conducted on 70 subjects. The MMP-9 and TIMP-1 levels in the amniochorion membrane were determined by ELISA. Results: The results of this study indicate that the amniochorion membrane in the incidence of premature rupture of membranes is characterized by increased levels of MMP-9, while TIMP-1 levels do not differ between the incidence of premature rupture of membranes. Conclusion: Based on the research that has been done, it can be concluded that there are differences in protein levels of MMP-9 but there are no differences in protein levels of TIMP-1 in premature rupture of membranes

10aMMP-910aPremature rupture of membranes.10aTIMP-11 aJoni, Meidrin1 aDarwin, Eryati1 aHerlambang, Herlambang1 aElliyanti, Aisyah uhttps://www.phcogj.com/article/2140