02061nas a2200229 4500008004100000024000700041245008900048210006900137260001700206300001200223490000700235520139400242653002101636653002001657653001201677100002301689700001501712700002201727700001901749700002301768856004001791 2023 eng d a2900aThe Relationship of the Gene Allele Apolipoprotein E with Height in Down Syndrome 210 aRelationship of the Gene Allele Apolipoprotein E with Height in  cOctober 2023 a897-9000 v153 a

Background: Apolipoprotein E (APOE) is a form of polymorphic protein located on the long arm of chromosome 19 at position 13.2 (19q13.2), translated into three alleles of the gene, namely normal allele 3 and dysfunctional allele 2 and 4. Patients with Down's Syndrome Trisomy 21 may have different allele frequencies and combinations of APOE gene genotypes with controls, which can result in decreased cognitive function and inhibition of bone growth. This study aims to analyze the relationship of the Apolipoprotein E Gene Allele with the height of patients with Down Syndrome Trisomy 21. Methods: This research is a cross sectional study with a comparative cross-sectional study design. Results: The sample used was the result of DNA extraction of patients with Down's Syndrome Trisomy 21 as many as 33 samples and 33 controls stored in the Biomedical Laboratory, Faculty of Medicine, Andalas University, Padang, Indonesia. The next step is to examine the APOE gene polymorphisms using PCR and sequencing techniques. The results showed that there was a significant relationship between the APOE gene allele and height (p=0.009). Conclusion: This study concluded that there was a significant relationship between the APOE gene allele and the height of patients with Down Syndrome Trisomy 21.

10aApolipoprotein E10aDown's Syndrome10aHeight.1 aMeinapuri, Malinda1 aAmir, Arni1 aChundrayetti, Eva1 aEfrida, Efrida1 aSusmiati, Susmiati uhttps://www.phcogj.com/article/2137