02440nas a2200241 4500008004100000024000700041245011900048210006900167260001700236300001200253490000700265520169000272653002701962653001601989653002002005653003102025653001802056100002402074700001902098700002002117700002102137856004002158 2023 eng d a1600aAnalysis of the Phytochemical and Antibacterial Properties of the Indigenous Mizo Medicinal Plant, Helicia Excelsa0 aAnalysis of the Phytochemical and Antibacterial Properties of th cOctober 2023 a823-8280 v153 a

Background: Helicia excelsa (Roxb.) Bl. is a scarcely known medicinal plant and is native to Southeast Asia. It is most notably used for the treatment of gastric problems in the Mizo traditional medicine in India. Method: The leaves of H. excelsa were collected from Aizawl, Mizoram, India. An extract was prepared using chloroform. Qualitative phytochemical tests were performed to detect the important phytocompounds. The antioxidant activity was determined by total phenolic content, total flavonoid content, total antioxidant content, DPPH- and ferric-reducing antioxidant power. Antibacterial activity was evaluated by agar well-diffusion method. Results: H. excelsa leaf contains amino acids, alkaloids, carbohydrates, glycosides, phenols, phytosterols, proteins, and tannins. It showed inhibition in selected Gram-negative and Gram-positive bacteria. The phenol, flavonoid and total antioxidant contents were 4.52±0.09 gallic acid equivalent (GAE mg/g), 64.27±1.04 quercetin equivalent (QE mg/g), 11.39±0.45 ascorbic acid equivalent (AAE mg/g) respectively. IC50 value of DPPH-scavenging activity was 5.67±0.36. The ferric ion-reducing power showed concentration-dependent activity. The plant extract showed growth-inhibitory actions against Gram-negative bacterium, Escherichia coli, and Gram-positive species, Bacillus cereus and Staphylococcus aureus. :Conclusion H. excelsa leaf contains important bioactive compounds that need to be identified. The antioxidant and antibacterial activities support the basis of its medicinal application.

10aAntibacterial activity10aAntioxidant10aHelicia excelsa10aMizo traditional medicine.10aPlant extract1 aTlau, Lalbiakngheti1 aLalawmpu, Lucy1 aLalthanpu, P.B.1 aLalchhandama, K. uhttps://www.phcogj.com/article/2124