02671nas a2200313 4500008004100000024000700041245016700048210006900215260001700284300001200301490000700313520166500320653002301985653001602008653001402024653001402038653002102052653001402073100003002087700002602117700003302143700003102176700002902207700001902236700001802255700001902273700002502292856004002317 2023 eng d a1300aPhytochemical Screening and Antiinflammatory Activity of the Extract from the Leaves of Desmodium molliculum (Kunth) DC (Fabaceae) in Rats with Acute Inflammation0 aPhytochemical Screening and Antiinflammatory Activity of the Ext cOctober 2023 a786-7900 v153 a

Inflammation and pain are the initial response mechanisms to environmental aggression on the human body. The traditional use of plants such as Desmodium Molliculum (Kunth) DC, among the Peruvian population for the treatment of inflammatory diseases, has occurred since ancient times. The objective of this research was to determine the presence of secondary metabolites and evaluate the antiinflammatory activity of Desmodium molliculum (EDM) leaves in rats with acute inflammation induced using carrageenan. The phytochemical profile was performed for the main secondary metabolites with biological activity. Subsequently, 25 rats were divided into 5 groups and treated as follows: Group I and II: Physiological Saline Solution (PSS) by oral administration. Group III: Sodium Diclofenac (25 mg/kg body weight) by intraperitoneal administration. Group IV and V: EDM at 250 mg/kg bw and 500 mg/kg bw by oral administration, respectively; 30 minutes after administration, acute inflammation was induced in Groups II, III, IV, and V using the subplantar edema technique with 1% w/v carrageenan. The volume displaced by the hind paw was evaluated in all 5 groups using a digital plethysmometer every 60 minutes for 5 hours. The results were obtained from the displaced volume (Mean ± SD), with the most representative values obtained at 240 minutes, where EDM at 250 mg/kg (0.57 ± 0.07 ml) bw and 500 mg/kg bw (0.578 ± 0.051 ml) showed significant anti-inflammatory activity (ANOVA p<0.05). We concluded that Desmodium Molliculum has anti-inflammatory activity at doses of 250 mg/kg bw and 500 mg/kg bw.

10aAcute inflammation10aCarrageenan10aDesmodium10aDog's Paw10aEdema Subplantar10aFabaceae.1 aOlascuaga-Castillo, Karyn1 aCastillo-Medina, Olga1 aVillacorta-Zavaleta, Marleni1 aSarmiento, Dan, Altamirano1 aCaceres-Andonaire, Elena1 aLlontop, Maria1 aMalca, Fatima1 aNoe, Sebastian1 aBlanco-Olano, Cyntia uhttps://www.phcogj.com/article/2119