02475nas a2200253 4500008004100000024000700041245018100048210006900229260001700298300001200315490000700327520159600334653003401930653002501964653002001989653003402009653003602043100002002079700002402099700001702123700000502140700003602145856004002181 2023 eng d a0700aSupplementation of Caesalpinia Sappan L. Extract to Increase Superoxide Dismutase Activity and Suppress Malondialdehyde Levels in Sprague Dawley Exposed to Inhaled Formaldehyde0 aSupplementation of Caesalpinia Sappan L Extract to Increase Supe cOctober 2023 a750-7550 v153 a

Introduction: It is not yet known how Caesalpinia sappan L. extract (CSE) affects the activity of SOD and MDA levels in rats exposed to inhaled formaldehyde. Method: This true experimental study in vivo uses a randomized post-test-only control group design. The subjects were male Sprague Dawley, 2-4 months old, weight 200-300 grams, a total of 30 heads divided into 6 experimental groups. The treatment group was given CSE at doses of 0, 100, 400, and 1000 g/kg BW for 28 days, and exposed to inhaled formaldehyde for 2 weeks, and 8 hours/day. SOD and MDA were measured using the ELISA kit. Statistical analysis used Kruskall Wallis, Mann Whitney, and rank spearman tests with α= 5%. Results: The highest average SOD was in the CSE 1000 group and the lowest was in the negative control group. The highest average MDA levels were in the negative control group and the lowest was in the positive control group. The difference in SOD levels between groups with a p-value = 0.016, while the difference in MDA between groups has a p-value of 0.915. the p-value of the relationship between SOD levels and MDA levels is 0.02 (correlation coefficient = -0.422). Conclusion: Caesalpinia sappan L. extract can increase the activity of superoxide dismutase enzymes but has not been able to suppress malondialdehyde levels. There was an association of increased superoxide dismutase enzyme activity with decreased malondialdehyde levels in Sprague Dawley exposed to inhaled formaldehyde

10aCaesalpinia Sappan L. Extract10ainhaled formaldehyde10aSprague Dawley.10aSuperoxide Dismutase Activity10aSuppress Malondialdehyde Levels1 aNurullita, Ulfa1 aSusilaningsih, Neni1 aSuwondo, Ari1 a1 aDjati, Kisdjamiatun, Retna Must uhttps://www.phcogj.com/article/2113