02359nas a2200229   4500008004100000024000700041245011800048210006900166260001400235300001200249490000700261520162800268653002401896653002001920653002801940653001901968653002101987100003402008700002202042700002502064856004002089       2023                        eng d  a3200aEffectivity of Patch Herbal Mixture Composed of Mangosteen Peel Extract and Bacterial Cellulose for Wound Healing0 aEffectivity of Patch Herbal Mixture Composed of Mangosteen Peel   cJune 2023  a461-4660 v153 a<p class="rtejustify">Indonesia has a very abundant production of mangosteen, which places at the 14th largest mangosteen production in the world. High mangosteen production affects the amount of mangosteen peel waste. On the other hand, mangosteen peel has been identified as a rich source in health benefits and has proven to be antibacterial, antifungal, antioxidant, anti-inflammatory, antitumor, and anti-carcinogenic. Traditionally, one of the conventional medicines used in wound dressings or infection medicine. It can be a possibility for patch wound healing development, especially for diabetic ulcers with an open wound, wetness, chronic infections, and high inflammation. This research aims to innovate wound dressings (patch) that contain active compounds from mangosteen peel as herbs with many active compounds to enhance the wound healing process with low toxic side effects. The patch developed from organic material from bacterial cellulose. The research was carried out with the initial process of making patches from bacterial cellulose (BC), then adding mangosteen peel extract as patch dressing with different concentrations (0%, 1%, 2%, 5%, and 10% v/v). Furthermore, the patch was applied to the injured Wistar rat, for 15 days. The wound area was measured using Image-J. The results of measuring the wound area showed significant wound improvement every day at each dose of the mangosteen patch compared with the control group. The optimum dose that appears to be different from the control is 10% v/v mangosteen peel extract which has been able to leave 3% of the wound area on the 15th day.</p>
10aBacterial cellulose10aHerbal compound10aMangosteen peel extract10aPatch dressing10aWound treatment.1 aGondokesumo, Marisca, Evalina1 aAntonius, Yulanda1 aAgustin, Yuana, Elly  uhttps://www.phcogj.com/article/2058