02592nas a2200289   4500008004100000024000700041245015200048210006900200260001400269300001200283490000700295520165500302653001601957653001601973653001601989653002302005100002902028700002602057700002902083700001902112700003402131700002002165700002602185700002102211700003002232856004002262       2023                        eng d  a0800aEffect of Single-Bulb Garlic (Allium sativum Var. Solo Garlic) Extract on The Hematological Profile In E-Cigarette-Induced Male Sprague Dawley Rats0 aEffect of SingleBulb Garlic Allium sativum Var Solo Garlic Extra  cJune 2023  a296-3000 v153 a<p class="rtejustify">Garlic and its derivative preparations have long been used in traditional medicine for good health. Garlic is known to act as an antioxidant, antitumor, antibacterial, and antifungal. The antioxidant compound in singlebulb garlic is considered to be better than the antioxidant content in other species of garlic. This research aimed to study the effect of hematological profile in oral administration of single-bulb garlic extract in e-cigarette-induced male <em>Sprague Dawley</em> rats. The method used in this study was randomized post-test only control group design. Twenty-four rats were randomly distributed into six groups. The group consisted of C (-) as normal rats’ control; C (+) only exposed to e-cigarette smoke; T1 exposed to e-cigarette smoke and treated with vitamin C; T2 exposed to e-cigarette and treated with single-bulb garlic extract 75 mg/kg BW; T3 exposed to e-cigarette and treated with single-bulb garlic extract 100 mg/kg BW; and T4 exposed to e-cigarette and treated with single-bulb garlic extract 125 mg/kg BW. Exposure to e-cigarette smoke is conducted by evaporating the liquid into a gas chamber with a nicotine dose of 3.6 mg/ml. All treatments were given for 14 days. On the 15th day, the rats were sacrificed. Blood samples were collected by the cardiac puncture method and were examined using a hematology analyzer. Data obtained were white blood count (WBC), platelets, hemoglobin, hematocrit, and erythrocytes that were analyzed with one-way ANOVA. The result of this study is that garlic extract may boost immunity in the body. However, higher doses can be toxic to erythrocytes.</p>
10aAntioxidant10aE-cigarette10aGood health10aHematology profile1 aYunita, Maya, Nurwartant1 aFauzi, Julia, Calvina1 aRahmania, Zahra, Defitra1 aSafinda, Bella1 aSholikhah, Tridiganita, Intan1 aAgustono, Bodhi1 aYuliani, Gandul, Atik1 aChhetri, Shekhar1 aRahmaniar, Reina, Puspita  uhttps://www.phcogj.com/article/2034