02828nas a2200349 4500008004100000024000700041245010700048210006900155260001500224300001200239490000700251520186400258653002202122653001402144653001602158653001702174653001602191653001602207653001502223653003602238653002102274653001502295653001502310653001402325653002502339653001802364100000502382700001802387700001702405700001602422856004002438 2023 eng d a2300aComplete Blood Profile after administration of Hydrocotyle sibthorpioides Lam. extract in capsule form0 aComplete Blood Profile after administration of Hydrocotyle sibth cApril 2023 a375-3830 v153 a

Pegagan embun (Hydrocotyle sibthorpioides Lam.) has been studied as an immunostimulant, increasing macrophage cell activity and phagocytosis capacity. Based on that circumstance, the study aims to prove the immunostimulating effect by measuring the activity of Hydrocotyle sibthorpioides Lam. extract in the capsule for the complete blood profile of healthy volunteers. The number of volunteers used was twenty people, and the volunteers were divided into two groups. The first group was given a placebo capsule without Hydrocotyle sibthorpioides Lam. extract. The second group was given a capsule with Hydrocotyle sibthorpioides Lam. extract with a dose of 67 mg, which was taken once a day for three days. Blood sampling was obtained before and after taking the capsule preparation. Observation of the complete blood profile was conducted by investigating changes in blood parameters such as haemoglobin levels, number of erythrocytes, number of leukocytes, hematocrit values, number of thrombocytes and the percentage of leukocyte types (banded neutrophils, segmented neutrophils, eosinophils, basophils, monocytes, and lymphocytes). The second group given Hydrocotyle sibthorpioides Lam. extract showed a significant effect on the increase in haemoglobin levels, number of thrombocytes and hematocrit values (p<0.05). The percentage of leukocyte type values showed that lymphocytes increased significantly (p<0.05). In contrast, the segmented neutrophil increased but did not show a significant difference with the percentage of banded neutrophils, eosinophils, basophils and monocytes (p>0.05). There was a nonsignificant result in all parameters for the first group, which was administrated with a placebo capsule without Hydrocotyle sibthorpioides Lam. extract.

10aBanded neutrophil10aBasophils10aEosinophils10aerythrocytes10aHaematology10aHaemoglobin10aHematocrit10aHydrocotile sibthorpioides Lam.10aImmunostimulants10aLeukocytes10aLymphocyte10aMonocytes10aSegmented neutrophil10aThrombocytes.1 a1 aFauzan, Adrul1 aUmar, Salman1 aAldi, Yufri uhttps://www.phcogj.com/article/2012