02289nas a2200217 4500008004100000024000700041245015100048210006900199260001500268300001200283490000700295520158500302653001801887653001601905653001701921100002001938700002701958700002001985700002602005856004002031 2023 eng d a2200aThe Effect of Combination between Green Tea Extract and Curcumin Extract from Mt. Lawu on BAX, Bcl-2 and Caspase-3 in Cisplatin-Induced Rat Models0 aEffect of Combination between Green Tea Extract and Curcumin Ext cApril 2023 a370-3740 v153 a

Introduction: The study determines effect of Combination between Green Tea and Curcumin Extract from Mount Lawu on BAX, Bcl-2 and Caspase-3 in Cisplatin (Cis)-induced rat models. Methods: We treated four rats in each group and randomly distributed them into four groups: group C (−) was the negative control group with no treatment given, group C (+) was the positive control group given Cis only, group A1 was given green tea extract and curcumin extract combination after Cis, and group A2 was given Ginkgo biloba after Cis. Expression levels of BAX, Bcl-2, and Caspase-3 were assessed by ELISA. An ANOVA, a parametric test, was used if the data were normally distributed. If there were significant differences between the three groups regarding BAX, Bcl-2 and Caspase-3, a post hoc test was performed to determine the differences between treatments. Results: The results of the study show that combination between green tea and curcumin extract can increase Bcl-2 levels with an average value of 15.42 + 0.76 ng/mL, better than Ginkgo biloba extract with a value of 13.50 + 0.47 ng/mL, reduce BAX and Caspase-3 levels with a value of 6.57 + 0.38 ng/mL and 2.89 + 0.19 ng/mL, better than Ginkgo biloba with a value of 7.34 + 1.06 ng/mL and 3.86 + 0.34 ng/mL. Conclusion: This research shows that Combination between Green Tea and Curcumin Extract can increase Bcl-2 levels and reduce BAX and Caspase-3 in Cis rat models after fourteen days of treatment, better than Ginkgo biloba.

10aAntiapoptotic10aAntioxidant10aOtotoxicity.1 aPrimadewi, Novi1 aKariosentono, Harijono1 aProbandari, Ari1 aWiboworini, Budiyanti uhttps://www.phcogj.com/article/2011