02666nas a2200277 4500008004100000024000700041245011400048210006900162260001500231300001200246490000700258520181400265653001202079653001302091653001802104653002102122100003302143700002902176700000502205700002502210700003702235700002902272700002902301700001802330856004002348 2023 eng d a0500aThe Effect of Sapodilla Leaf Extract (Manilkara zapota L.) on Lipid Profiles of Alloxan-Induced Diabetic Mice0 aEffect of Sapodilla Leaf Extract Manilkara zapota L on Lipid Pro cApril 2023 a286-2890 v153 a

The aim of this study is to examine the effect of sapodilla leaf extract on lipid profiles of alloxan-induced diabetic mice. This research method are 30 male mice were used as experimental animals, which were randomly divided into five groups, each group consisting of 6 mice. The division of the group is as follows: Treatment of non-diabetic mice, diabetic mice, diabetic mice by administering pioglitazone at a dose of 2 mg/kg BW, extracts of manila sapodilla leaf (M. zapota L.) dose 100 mg/kg BW and 300 mg/kg BW. Observations were made on the 14th day, after administration of sapodilla leaf extract, mice were given light anesthesia and serum lipid profiles Total Cholesterol (TC), triglycerides (TG), High-Density Lipoprotein (HDL), and Low-Density Lipoprotein (LDL) were measured using diagnostic kits (Pars Azmoon Kit) and automatic analyzer (Abbot, model Alcyon 300). The results of this study are in TC, there was a significant difference in pioglitazone and 100 mg leaf extract against all treatment groups. In TG, there was a significant difference in pioglitazone and 300 mg leaf extract against all treatment groups. In LDL, there were significant differences in the 100 mg, 300 mg leaf extract and pioglitazone, against negative control, and diabetes control. In HDL, there was a significant difference in negative control and 300 mg leaf extract, against 100 mg leaf extract, pioglitazone, and diabetes control. The conclusions of this study exhibited the ethanol extract of M. zapota leaves contains several phytochemical compounds including alkaloids, flavonoids, saponins, polyphenols, tannins, quinones, and steroids. M. zapota leaves extract (100 mg/kg and 300 mg/kg) exhibited a significant effect on improvement in lipid protein.

10aAlloxan10aDiabetes10aLipid Protein10aManilkara zapota1 aSolikhah, Tridiganita, Intan1 aWijaya, Tania, Anggreani1 a1 aPavita, Daffa, Alice1 aMiftakhurrozaq, Ragil, Kusnandar1 aRaharjo, Hartanto, Mulyo1 aYunita, Maya, Nurwartant1 aFikri, Faisal uhttps://www.phcogj.com/article/1994