02680nas a2200193   4500008004100000024000700041245011200048210006900160260001500229300001200244490000700256520207400263653001002337653003002347653002602377100001902403700002402422856004002446       2023                        eng d  a3300aEffect of Platelet Concentrates (PCs) Leucodepletion on the Activation and Efficacy of Platelet Transfusion0 aEffect of Platelet Concentrates PCs Leucodepletion on the Activa  cMarch 2023  a223-2270 v153 a<p class="rtejustify">Platelet concentrates (PCs) are blood components transfused in thrombocytopenic patients, including patients with blood malignancies. PCs contain leukocytes, which can pose potential side effects and activate platelets, reducing the efficacy of platelet transfusion. The leucodepletion process can be carried out by filtration to reduce the leukocyte count. This study aims to determine the difference between the CD62P expression of nonleucodepleted and leucodepleted PCs and to determine the difference between the Corrected Count Increment (CCI) of patients transfused with nonleucodepleted and leucodepleted PCs. This analytic observational study with a cross-sectional design was carried out on PCs obtained from platelet-rich plasma (PRP-PC). PCs were transfused into 48 blood malignancy patients, Yogyakarta, consisting of two groups i.e the group transfused with nonleucodepleted PCs (24 patients) and the group transfused with leucodepleted PCs (24 patients). CD62P expression in PCs was measured by flow cytometry method, and the CCI of the patients was calculated based on the CCI formula. The difference between the median CD62P expression and CCI of the two groups was analyzed using the Mann- Whitney Test with a significance of p&lt;0.05. The median CD62P expression of the nonleucodepleted and leucodepleted groups were 34.4% (16.8–94.4%) and 21.7% (6.2–34.0%), respectively. There was a statistically significant difference between the CD62P expression of the two groups (p = 0.00). The group transfused with nonleucodepleted, and leucodepleted PCs showed respective median CCI of 18.8 x 10<sup>9</sup>/L (2.4–94.8 x 10<sup>9</sup>/L) and 14.7 x 10<sup>9</sup>/L (2.4–124.0 x 10<sup>9</sup>/L). There was no statistically significant difference between the CCI of the two groups (p = 0.42). It can be concluded that the CD62P expression in the PCs of the leucodepleted group was significantly lower than those of the nonleucodepleted group and that there was no significant difference between the CCI of both groups.</p>
10aCD62P10aCorrected count increment10aPlatelet concentrates1 aTriyono, Teguh1 aRofinda, Zelly, Dia  uhttps://www.phcogj.com/article/1985