02157nas a2200217 4500008004100000024000700041245010600048210006900154260001500223300001200238490000700250520150300257653001601760653001901776653001001795653001901805653002701824100002601851700002201877856004001899 2023 eng d a2600aAnalysis of Royal Jelly Apis Cerana as Therapeutic Candidate in Cbavd Based on Bioinformatics Studies0 aAnalysis of Royal Jelly Apis Cerana as Therapeutic Candidate in  cMarch 2023 a175-1820 v153 a

Background: Apis cerana honey bee is a honey bee native to Asia that spreads from Afghanistan, China, and Japan to Indonesia. The productivity of Apis cerana honey bees can produce as much as 2-5 kg of honey per colony in a year. Royal jelly is the queen's nourishment, and it is produced by larvae, adult bees, young worker bees, and male bee larvae. CBAVD contributes to 1–2% of the 20–25% of males with subfertility. Aim: The objective of this study was to evaluate Royal Jelly Apis Cerana as a potential therapeutic candidate for CBAVD using a bioinformatics approach. Method: This research method consisted of converting nucleotides into amino acids, analyzing the three-dimensional structure of Apis Cerana Royal Jelly Protein, Ramachandran Plot Analysis, Analysis of Epitope and Allergen Proteins, and Analysis of Proteins that were antigens and toxins. Results: The research results were conducted on six three-dimensional Apis Cerana Royal Jelly bee protein structures and had very good validity based on the Ramachandran plot, GQME value, and QmeanDisCo value. In addition, this study also obtained the results of proteins that are epitope, antigenic, non-allergenic, and non-toxic. Conclusion: The findings of this study can be used as a basis for therapy against CBAVD.

10aApis Cerana10aBioinformatics10aCBAVD10aPublic health.10aTherapeutic Candidates1 aMafruchati, Maslichah1 aMakuwia, Jonathan uhttps://www.phcogj.com/article/1978