02534nas a2200253 4500008004100000245008700041210006900128260001300197300001200210490000600222520180900228653001902037653002102056653002102077653002002098653001002118100002602128700002002154700001502174700001502189700001502204700002202219856003902241 2016 eng d00aEvaluation of Costus speciosus in Experimental Models of Depression in Albino Mice0 aEvaluation of Costus speciosus in Experimental Models of Depress cOct 2016 a483-4860 v83 a

Introduction: Despite theavailability of numerous antidepressant drugs the therapy of depression is far from satisfactory. Two of the many reasons for this are the delay in onset of effect and the adverse effects associated with most of the antidepressants. Costus speciosus rhizome has shown adaptogenic activity. Objective: To evaluate the antidepressant activity of50% aqueous-ethanol extract of Costus speciosus (CS) leaves in experimental models of depression. Materials and Methods: Male albino mice were randomly assigned to five groups of six each. We studied three doses of the leaf extract (100, 200 and 400 mg/kg) on two models of depression – forced swim test and tail suspension test. Imipramine was used as the standard control. Both acute and chronic effects were studied. Drugs (test drug, standard control and vehicle) were administeredorally, one hour before the experiment in the acute study and daily for 14 days for the chronic study. Results: Imipramine showed significant antidepressant activity as demonstrated by a reduction in duration of immobility in both acute and chronic studies of forced swim test and tail suspension test. CS showed a dose dependent antidepressant activity. CS_100 demonstrated an antidepressant effect only in the acute forced swim test. CS_200 demonstrated an antidepressant activity in both acute and chronic forced swim test but not in tail suspension test. CS_400 showed maximum antidepressant activity in both acute and chronic studies, which was comparable to that of the standard drug imipramine. Conclusion: CS showed dose dependent antidepressant activity with CS_400 mg/kg showing maximum effect.

10aAntidepressant10aCostus speciosus10aForced swim test10aTail suspension10aTest.1 aRather, Zahoor, Ahmad1 aM, Nateshprabhu1 aDS, Sushma1 aKb, Rakesh1 aPai, Sunil1 aD, Ullal, sheetal uhttps://www.phcogj.com/article/195