02537nas a2200301 4500008004100000024000700041245011400048210006900162260001700231300001200248490000700260520161100267653002601878653002201904653001201926653002601938653002401964653002601988100002502014700002302039700002102062700002202083700002202105700002402127700002402151700002002175856004002195 2022 eng d a2000aAntioxidant, Antimicrobial, and Antiplasmodial Activities of Sonchus arvensis L. Leaf Ethyl Acetate Fractions0 aAntioxidant Antimicrobial and Antiplasmodial Activities of Sonch cJanuary 2023 a993-9980 v143 a

Infection is one of the health problems and a disease that mainly causes death. Malaria is a parasitic infection that is transmitted through the Anopheles sp. The female then causes infection and besides malaria, other contaminants that caused infection are bacteria such as Escherichia coli and Staphylococcus aureus. This study aims to determine the antioxidant, antimicrobial, and antiplasmodial activity of Sonchus arvensis L. ethyl acetate fractions. In vitro antiplasmodial activity was carried out by Rieckman methods against Plasmodium falciparum strain 3D7. In vitro antioxidant activity was conducted by Prieto method against (1,1-diphenyl-2-picrylhydrazyl (DPPH). Then antimicrobial activity was performed using well diffusion method against Escherichia coli and Staphylococcus aureus. Maceration of S. arvensis L. dried leaves used n-hexane and ethyl acetate successively. Then the ethyl acetate extract was fractionated by vacuum column chromatography, using n-hexane and ethyl acetate as mobile phases. There are five fraction groups based on thin-layer chromatography (TLC) analysis. The IC50 of antioxidant and antiplasmodial activity showed that fraction IV was the lowest value and categorized as active for antioxidant (IC50=22.56 μg/mL), for antiplasmodial (IC50=12.07 μg/mL). Fraction IV also had antimicrobial activity, with diameter of inhibition zone (DIZ) of 19.22 mm against Escherichia coli and 17.167 mm against Staphylococcus aureus.

10aBiological activities10aEscherichia coli.10aMalaria10aPlasmodium falciparum10aSonchus arvensis L.10aStaphylococcus aureus1 aWahyuni, Dwi, Kusuma1 aNariswari, Anindya1 aSupriyanto, Agus1 aPurnobasuki, Hery1 aPunnapayak, Hunsa1 aBankeeree, Wichanee1 aPrasongsuk, Sehanat1 aEkasari, Wiwied uhttps://www.phcogj.com/article/1941