02642nas a2200265 4500008004100000024000700041245015700048210006900205260001800274300001200292490000700304520177300311653002102084653002002105653001202125653002002137653003102157100002902188700001802217700002202235700002502257700003002282700002402312856004002336 2022 eng d a1400aThe Effects of Leaves Extract of Toddalia aculeata on Body Weight, Body Mass Index, Body Fat Content and Resistive Index in Male Rats with High-Fat Diet0 aEffects of Leaves Extract of Toddalia aculeata on Body Weight Bo cDecember 2022 a771-7770 v143 a

Introduction: Dictamine is found in the Toddalia aculeata plant and is able to interact with Flavin- Containing Monooxygenase-3 (FMO3) in silico, which mediates endogenous atherosclerosis formation. Therefore, this study aimed to investigate the effects of T. aculeata extract (TAE) administration on Body Weight (BW), Body Mass Index (BMI), Body Fat Content (BFC), and Resistive Index (RI) in rats with a high-fat diet. Methods: Forty male Sprague-Dawley rats were randomly divided into the negative control (NC), positive control (PC) + 2.98 μg/kg BW dictamine and treatment (TAE1-3) + 200, 400, and 800 mg/ kg BW TAE respectively. All rats were given a high-fat diet (HFD) for 28 days. The data were analyzed statistically using one-way ANOVA, repeated-measured ANOVA, and Friedman’s tests with p<0.05. Results: The average of rats’ BW in TAE2 (270±13.78 g) and TAE3 (276.62±40.31 g) was lower than that of the NC (304.12± 4.16 g) but only the TAE2 group was significantly different (p=0.032). Rats in the TAE 1-3 groups had the average BMI (26.03±5.61; 21.84±0.81; 20.78±2.17 g/cm3) significantly lower than the NC (29.61±2.28 g/cm3) and the PC (28.67±1.68 g/cm3) for TAE2 and 3. The same pattern was also observed in BFC. All treatment groups had significantly lower RI compared to the NC group (0.62±0.07 cm). Conclusion: Administration of 400 and 800 mg/kg BW TAE for 28 days decreases BW, BMI, BFC, and RI in rats with a high-fat diet. Dictamine in the ethanol extract of T. aculeata leaves might contribute to the reduction of RI in rats with a high-fat diet.

10aBody Fat Content10aBody Mass Index10aObesity10aResistive Index10aToddalia Aculeata Extract.1 aPutro, Prasetyo, Sarwono1 aIndarto, Dono1 aPurwanto, Bambang1 aSoewondo, Widyastuti1 aKusumaningrum, Sulistyani1 aNguzum, Khim, Yatul uhttps://www.phcogj.com/article/1907