03028nas a2200253 4500008004100000024000700041245008600048210006900134260001700203300001200220490000700232520227900239653001602518653002702534653002102561653002202582653001202604100003002616700002702646700002202673700002002695700001902715856004002734 2022 eng d a1800aEffect of Crataegus aronia on the Biochemical Parameters in Induced Diabetic Rats0 aEffect of Crataegus aronia on the Biochemical Parameters in Indu cOctober 2022 a587-5950 v143 a

Crataegus aronia is widely known for its antioxidant, anti-inflammatory, and hypolipidemic properties, and it has traditionally been used to treat cardiovascular disorders. This study aimed to evaluate the impact of Crataegus aronia extract on the liver enzyme markers, blood glucose levels, lipid profiles, and kidney function biomarkers as well as hematological parameters in induced diabetic rats. Male Wistar rats were divided into seven groups: normal Control; Diabetic; and Diabetic animals treated with two doses of Crataegus aronia extract (5 and 10mg/kg) (DM + extract), Control treated with the extract ( 5 and 10mg/ kg) and induced diabetic treated with insulin. Streptozotocin (STZ)-induced diabetic rats (50 mg/kg, ip)and normal were orally administrated with Crataegus aronia extract once a day for 4 weeks. At the end of the experiment, the biochemical and hematological parameters were measured in all groups. Also, the phytochemicals and antioxidant activity of the Crataegus aronia extract were evaluated. According to findings, the total phenols, total flavonoid, and flavonol contents were 538.3 mg Galic acid equivalent /g extract, 149.3 mg Rutin equivalent / g extract, and 79.3 mg Rutin equivalent / g extract), respectively. The antioxidant activity according to 2,2-diphenyl-2-picrylhydrazyl (DPPH) IC50 and ferric reducing antioxidant power (FRAP) assays were 28.02 μg/ml and in the range of 0.273 – 0.960 μmol Fe+2/g dw, respectively. Crataegus aronia extract significantly (p <0.05) affects red blood cells, hemoglobin, hematocrit, white blood cells, lymphocytes, and platelets values. Also, Crataegus aronia had a significant (P < 0.05) effect on serum biochemical parameters, including glucose, total proteins, albumins, triglycerides, creatinine, bilirubin, and serum aspartate aminotransferase (AST). However, Crataegus aronia treatment had no significant effects (p < 0.05) on serum alanine aminotransferase, alkaline phosphatase, and cholesterol levels. Crataegus aronia exerts antioxidant activity and significantly improves the biochemical and hematological biomarkers in induced diabetic rats.

10aAntioxidant10aBiochemical parameters10aCrataegus aronia10aDiabetes mellitus10aInsulin1 aAl-Mobideen, Omar, Khaled1 aAlqudah, Ali, Abdallah1 aAl-Mustafa, Ahmed1 aAlhawarat, Fuad1 aMizher, Hussam uhttps://www.phcogj.com/article/1875