01828nas a2200229   4500008004100000024000700041245006300048210006300111260001700174300001200191490000700203520118700210653001201397653002601409653001401435653001701449100002301466700002501489700002201514700002201536856004001558       2022                        eng d  a1300aArtificial Sweeteners Perturbed Liver Enzymes in Rat Model0 aArtificial Sweeteners Perturbed Liver Enzymes in Rat Model  cOctober 2022  a553-5570 v143 a<p class="rtejustify">In the recent time there has been an increased demand of low-fat or low calorie diet universally. In the mean while the availability of low calorie products has also increased like sugar free drinks, beverages, biscuits, jams and jellies. On contrary to this, some studies suggest that the prolong use of non-nutritive sweeteners alters the homeostasis of glucose and insulin. It results in fluctuation of glucose level in blood and increase in bodyweight. This study intends to evaluate the effect of non-nutritive sweeteners on the liver function test and record the alteration in the levels of ALP, AST and ALT. Seventy rats were divided into seven equal groups, controlled group received distilled water and the rest six were given NNS Sucrose, Stevia, Sucralose, Saccharine Aspartame and Acesulfame-k, respectively. On the evaluation of Alanine aminotransferase ALT, saccharine and aspartame markedly increased the level of ALT from 40U/L to 80 U/L. Both of these NNS have shown the most raised level of Alanine aminotransferase. This represents the stress on the liver associated with the use of NNS and suggests the use to be controlled in humans.</p>
10aAlbumin10aArtificial Sweeteners10aBilirubin10aLiver Enzyme1 aDawood, Muthear, N1 aJassim, Shaymaa, AH.1 aFadel, Maab, Azmi1 aThanoon, Imad, A.  uhttps://www.phcogj.com/article/1870