02421nas a2200265 4500008004100000024000700041245014300048210006900191260001700260300001200277490000700289520155800296653002301854653002701877653002101904653003901925100001801964700001901982700001602001700002302017700002102040700002302061700003102084856004002115 2022 eng d a0100aAnalysis of LH Receptor Expression in the Testes of Infertile Azoospermic Non-Obstructive (NOA) Men at High Serum Prolactin Concentrations0 aAnalysis of LH Receptor Expression in the Testes of Infertile Az cOctober 2022 a462-4680 v143 a

Background: Hyperprolactin is one of the endocrine disorders that causes male infertility (11%). The mechanism is not widely known; it is thought to occur through disruption of LH receptor activity on germ cells. Objective: The aim of study to compare the level of prolactin secretion with receptor expression in non-azoospermic infertile men (NOA). Methods: During the period from July 2019 to July 2021, 40 samples of testicular tissue and serum were obtained from infertile NOA men, aged 25-50 years who were recruited from Ciptomangunkusumo Hospital (RSCM) Jakarta, Faculty of Medicine, Universitas Indonesia and Bunda Hospital Jakarta. Subjects were divided into 4 groups based on prolactin levels (20 ng/ml, 20-50 ng/ml, 50-100 ng/ml and 100ng/ml). This group was tested for significance between groups and continued with a correlation test with the level of LH receptor expression. Results: ANOVA test showed a significant decrease in LH receptor expression between prolactin levels < 20 ng/mL with levels of 50-100 ng/ml and prolactin levels > 100 ng/ml (P < 0.05). Furthermore, the results of the correlation test showed a significant decrease between prolactin levels and LH receptor expression (P < 0.05). Conclusion: The higher the level of prolactin secretion in this sample, there is a decrease in LH receptor expression, so that testosterone production decreases and the spermatogenesis process will be disrupted.

10aHyperprolactinemia10aLH receptor expression10aMale infertility10aNon obstructive azoospermia (NOA).1 aBirowo, Ponco1 aSahar, Nurhuda1 aMuharam, R.1 aPujianto, Dwi, Ari1 aThuffi, Rosalina1 aKusmardi, Kusmardi1 aTjempakasari, Conny, Riana uhttps://www.phcogj.com/article/1858