02093nas a2200253 4500008004100000245012100041210006900162260001600231300001200247490000700259520133800266653001701604653002701621653001301648653001901661653001101680653000901691653001201700100002301712700002701735700002101762700001601783856004001799 2022 eng d00aThe Effect of Omega-3 Rich Fish Oil on the Kidney Changes in Mice Induced by Azoxymethane and Dextran Sodium Sulfate0 aEffect of Omega3 Rich Fish Oil on the Kidney Changes in Mice Ind cAugust 2022 a259-2660 v143 a

Background: The study aimed to investigate the effect of omega-3 rich fish oil to kidney of mice induced by Azoxymethane (AOM) and DSS using histopathology parameters. Method: The experimental mice were induced using 10 mg/kg AOM and 2% DSS for 2 weeks randomly allocated randomly into four groups as follows; Control Group: mice that not received fish oil, Low Dose Group: mice that received 1.5 mg/day fish oil, Medium Dose Group: mice that received 3 mg/day fish oil, and High Dose Group: mice that received 6 mg/day fish oil. The omega-3 rich fish oil was given for 12 weeks. Result: The administration of high dose omega-3 rich fish oil was able to reduced necrosis and inflammation foci compared to the control group (p<0.05). Furthermore, the administration of low, medium, and high dose omega-3 rich fish oil was able to significantly reduced vascular edema and cell degeneration foci (p<0.05). The administration of medium and high dose of omega-3 rich fish oil were able to reduce the amount of fibrosis foci compared to the control group (p<0.05) compared to the control group. Conclusion: The result suggested anti-nephrotoxic effect of omega-3 rich fish oil in mice induced by azoxymethane and DSS.

10aAzoxymethane10aDextran sodium sulfate10aFish oil10aHistopathology10aKidney10aMice10aOmega-31 aKusmardi, Kusmardi1 aHalim, Paulus, Anthony1 aPutranto, Wachid1 aTedjo, Aryo uhttps://www.phcogj.com/article/1831