02049nas a2200205   4500008004100000245007100041210006900112260001400181300001200195490000700207520145900214653001301673653001301686653001301699653002501712653001501737100002801752700002301780856004001803       2022                        eng d00aRole of Alkaloid on Platelet Aggregation and Serotonin in Migraine0 aRole of Alkaloid on Platelet Aggregation and Serotonin in Migrai  cJune 2022  a629-6320 v143 a<p class="rtejustify">Migraine is a sterile neurogenic inflammation of the trigeminal nerve which releases vasoactive neuropeptides and activates platelets to release vasoactive substances such as serotonin (5-HT). Platelet hyperaggregation occurs in the pathogenesis of migraine caused by one of the stimulatory factors 5-HT. Platelet aggregation is increased and 5-HT levels are elevated in the blood and brain in the early stages of migraine. Alkaloid β-carbolin alkaloids can increase monoamines in brain regions through inhibition of monoamine oxidase (MAO) and inhibition of 5-HT reuptake. Alkaloids in the ethanolic extract of SCE function as analgesics and anti-inflammatory which can reduce pain and improve blood circulation. <em>Sargassum cristaefolium</em> extract (SCE) was measured for its bioactive substance content. The extract was administered to an animal model of intraperitoneal nitroglycerin-induced migraine and examined for platelet levels, platelet aggregation and 5-HT. The results of statistical tests showed an increase in platelets (p&lt;0.05), an increase in platelet aggregation (p&lt;0.05) and a decrease in 5-HT (p&lt;0.05). The relationship between alkaloids and platelets; platelets and platelet aggregation; platelet aggregation and 5-HT and 5-HT levels and migraine incidence (p&lt;0.05). The alkaloids found in SCE can lower platelet count, decrease platelet aggregation and increase 5-HT levels in migraines.</p>
10aAlkaloid10aMigraine10aPlatelet10aPlatelet aggregation10aSerotonin.1 aAdam, Olivia, Mahardani1 aWidjiati, Widjiati  uhttps://www.phcogj.com/article/1811