02526nas a2200157 4500008004100000245015200041210006900193260001800262300001200280490000700292520194600299100003102245700002602276700002602302856004002328 2022 eng d00aPotential Pharmacokinetics and Pharmacodynamics (PK-PD) Drug-Herbs Interactions (DHI) from Metformin and Traditional Medicines: A Literature Review0 aPotential Pharmacokinetics and Pharmacodynamics PKPD DrugHerbs I cFebruary 2022 a235-2440 v143 a

Introduction: Metformin given together with herbs in order to optimizing its mechanism of actions. The effect might be positive and vice versa. Interaction might occur pharmacokinetics or pharmacodynamically. The study aimed to review potential interaction of metformin and some herbs with various pharmacological activities. Methods: This literature review was conducted by collecting articles with keywords Metformin, Herb-drug Interaction, drug interaction, pharmacokinetics, pharmacodynamics, and pharmacology from international databases such as Science Direct, PubMed, Springer Link, and Scopus up to 2021. Results: Metformin with its various uses such as antidiabetic agent, an agent for reducing weight for patients that sensitive or even resistant to insulin, patients with obesity, anti-tumor agent, anti-cancer potential agent, and also has anti-aging potential. Metformin could interacted with drugs, herbs, and also some bioactive isolate. The interaction might occurs pharmacokinetically or pharmacodynamically. Pharmacokinetics interactions occurred during distribution and also excretion via transporters that metformin transported with. This was shown as the elevated or lowered metformin levels in blood. Pharmacodynamic interactions can be seen as the lowering or elevated levels of glucose, HbA1c and even the lipid profile in blood or plasma. Conclusion: According to this literature review, Metformin have potential interaction with drugs, herbs, and also some bioactive isolate. The interactions occur pharmacokinetically or pharmacodynamically. This study can be used as a established familiarity with and understanding the potential HDIs from Metformin and herbal products.

Key words: Drug-Herbs Interactions (DHIs), Metformin, Pharmacokinetics, Pharmacodynamics.

1 aPramesthi, Asri, Dwi Endah1 aLukitaningsih, Endang1 aNugroho, Agung, Endro uhttps://www.phcogj.com/article/1757