02450nas a2200277 4500008004100000245015600041210006900197260001800266300001200284490000700296520163900303100000501942700001701947700001201964700001501976700000501991700002001996700001902016700001602035700001602051700001602067700001802083700001602101700001502117856004002132 2022 eng d00aThe Effect of Curcumin and Virgin Coconut Oil Towards Cytokines Levels in COVID-19 Patients at Universitas Sebelas Maret Hospital, Surakarta, Indonesia0 aEffect of Curcumin and Virgin Coconut Oil Towards Cytokines Leve cFebruary 2022 a216-2250 v143 a

Introduction: To date, no specific therapeutic drug has been approved to target SARS-CoV-2. Hence, it remains a major challenge to decide what potential therapeutic regimens to treat COVID-19 patients. This study aims to investigate curcumin and virgin coconut oil (VCO) effects on cytokine levels (IL-1β, IL-2, IL-6, IL-18, TNF-α, and IFN-β) in COVID-19 patients. Methods: This study was a single-center, controlled trial with a parallel Arm or a Randomized Clinical trial design. A total of sixty COVID-19 patients admitted to the Universitas Sebelas Maret Hospital, Surakarta, Indonesia, were divided into two groups. The first group, consisting of 30 patients, was treated with Azithromycin 500 mg + Oseltamivir 2×75 mg + Hydroxychloroquine 400 mg/day for 5 days. The second group, comprising 30 patients, was treated with Azithromycin 500 mg + Oseltamivir 2×75 mg + Hydroxychloroquine 400 mg/day for 5 days, added with VCO 30 mL and curcumin 3×1 g/day for 21 days. The cytokine profiles of the serum samples were analyzed by the enzyme-linked immunosorbent assay (ELISA) on days 1, 14, and 21. Results: Our study showed that the second group had a significant reduction in IL-1β, IL-2, IL-6, TNF-α, and IFN-β levels after being treated with standard therapy added with curcumin and VCO on day 21 (p<0.05). Conclusion: These results suggested that curcumin and VCO might benefit the treatment of COVID-19 patients.

Key words: COVID-19, Curcumin, Cytokines, Virgin coconut oil.

1 a1 aSuryawati, B1 aSari, Y1 aAvicena, A1 a1 aSukmagautama, C1 aApriningsih, H1 aShofiyah, L1 aNovika, RGH1 aWahidah, NJ1 aRahmawati, NY1 aAnsori, ANM1 aSumarno, L uhttps://www.phcogj.com/article/1755