02517nas a2200169 4500008004100000245013300041210006900174260001800243300001200261490000700273520196200280100000502242700002602247700002902273700000502302856004002307 2022 eng d00aThe Potency of Cinnamon Bark Oil (Cinnamomum burmannii (Nees & T. Nees) Blume) from 5 Regions in Indonesia as Anti- Inflammatory0 aPotency of Cinnamon Bark Oil Cinnamomum burmannii Nees T Nees Bl cFebruary 2022 a154-1640 v143 a

Introduction: An alternative anti-inflammatory with milder side effects is needed. One of them can be sourced from plants such as Cinnamomum spp. Indonesia is the largest producer of cinnamon bark (Cinnamomum burmannii (Nees & T. Nees) Blume) in the world. Thus, research is needed to increase the benefits and database of C. burmannii bark, especially as an anti-inflammatory. This study aims to determine the metabolite profile of the essential oil of C. burmannii bark (CBO) from 5 regions in Indonesia as an anti-inflammatory. Methods: The location of the sampling was carried out by fulfilling 3 criteria, namely the difference in the island, province, and the area that produces the bark of C. burmannii. Analysis was performed using GC-MS Agilent 7890B GC and 5977B MSD. A total of 40 male rats (Rattus novergicus) Wistar strain were divided into 8 groups, each group consisted of 5 rats. Group 1 as negative control treated with 1% CMC-Na solution, group 2 as positive control treated with ibuprofen at a dose of 27 mg/kg BW, Group 3, 4, 5, 6, 7, and 8 treated with CBO from 5 locations. After 30 min of treatment, experimental animals were injected left paw with carrageenan1%/100μl/paw. Measurements of left paw swelling were carried out at 1, 2, 3, and 4 hours and the animals were sacrificed. Edema inhibition percentage, number of inflammatory cells, and TNF-α expression were analyzed. Result: The results of this study indicate that CBO from 5 regions in Indonesia has anti-inflammatory properties. Conclusion: There was no significant difference in anti-inflammatory activity CBO from 4 regions, namely from Kerinci, Lombok Timur, Karanganyar, and Gorontalo areas.

Key words: Anti-inflammatory, Cinnamon bark Oil, Metabolite profile, Essential oil.

1 a1 aNurcholida, Rosy, Dwi1 aPrimaharinastiti, Riesta1 a uhttps://www.phcogj.com/article/1749