02134nas a2200217 4500008004100000245013200041210006900173260001800242300001400260490000700274520142800281653002601709653001701735653002301752653002701775100003301802700001701835700001901852700000501871856004001876 2021 eng d00aCharacterization and Phytochemical Screening of Meniran (Phyllanthus niruri Linn) Extract's Nanoparticles Used Ball Mill Method0 aCharacterization and Phytochemical Screening of Meniran Phyllant cDecember 2021 a1568-15720 v133 a

The aim of this study was to study the characterization and phytochemical screening of meniran (Phyllanthus niruri linn) extract's nanoparticles used ball mill method. The effect of herbal products would be maximized, a formulation that able to increase solubility, stability, bioavailability, and a targeted system was needed so the use of simplicia would be more effective. One of alternative solutions to this problem was to make the preparation of meniran extract in the form of nanoparticles. Nanoparticles made it easier for extract to be absorbed in blood plasma and were more effective in achieving the target drug itself. The manufacture of meniran nanoparticles used ball mill method. Then, meniran extract nanoparticles characterization and phytochemical screening were carried out. Meniran (Phyllanthus niruri Linn) extract nanoparticle characterization consisted of size, used Particle Size Analyzer (PSA), and morphology, used Scaning Electron Microscope (SEM). Phytochemical screening of meniran extract nanoparticles used qualitative screening by reagent test. The results showed that the meniran extract nanoparticles produced an average size of 192.6 nm. The averange shape of particle was imperfectly amorphous and the dominant composition was Carbon (C). Phytochemical screening showed the content of flavonoids, tannins, saponins, terpenoids and alkaloids.

10aBiological production10aNanoparticle10aPhyllanthus niruri10aPhytochemical compound1 aSabdoningrum, Emy, Koestanti1 aHidanah, Sri1 aChusniati, Sri1 a uhttps://www.phcogj.com/article/1706