01929nas a2200229 4500008004100000245007100041210006900112260001800181300001400199490000700213520124100220653001201461653002801473653002501501653001501526100003401541700001601575700001901591700002801610700002101638856004001659 2021 eng d00aTyrosinase Inhibitory Activity of Garcinia latissima Miq. Extracts0 aTyrosinase Inhibitory Activity of Garcinia latissima Miq Extract cDecember 2021 a1673-16770 v133 a

Background: Tyrosinase is an enzyme that plays an essential part in the process of melanin synthesis. High exposure to ultraviolet (UV) radiation or high stimulation of melanocytes could cause excessive melanin pigments to lead to hyperpigmentation. Objective: This study aimed to find potential natural skin lightening ingredients from Garcinia latissima Miq. Methods: Stem bark, fruits, and leaves of Garcinia latissima Miq. were extracted with successive maceration. The tyrosinase inhibitory activity test was measured spectrophotometrically at 490 nm using 3,4-dihydroxy-L-phenylalanine (L-DOPA) as substrate and kojic acid as a positive control. Results: The tyrosinase inhibitory activity test at a concentration of 100 ppm showed that the bark ethyl acetate extract 15.94% ± 7.70, bark methanol extract of 28.94% ± 5.73, fruit n-hexane extract 25.16% ± 10.22, fruit methanol extract 23.26% ± 9.10; and leaf methanol extract 30.59% ± 0.63 with kojic acid inhibition 65.07%. Conclusion: Methanol extract of leaf from Garcinia latissima Miq was the most active extract as a tyrosinase inhibitor.

10aExtract10aGarcinia latissima Miq.10aSuccesive maceration10aTyrosinase1 aAmbarwati, Neneng, Siti Silfi1 aElya, Berna1 aDesmiaty, Yesi1 aArifianti, Ayun, Erwina1 aAhmad, Islamudin uhttps://www.phcogj.com/article/1701